Article citationsMore>>
Kato, Y., Nagashima, Y., Baba, Y., Kawano, T., Furukawa, M., Kubota, A., Yanoma, S., Imagawa-Ishiguro, Y., Satake, K., Taguchi, T., Hata, R., Mochimatsu, I., Aoki, I., Kameda, Y., Inayama, Y. and Tsukuda, M. (2005) Expression of SPARC in Tongue Carcinoma of Stage II Is Associated with Poor Prognosis: An Immunohistochemical Study of 86 Cases. International Journal of Molecular Medicine, 16, 263-268.
https://doi.org/10.3892/ijmm.16.2.263
has been cited by the following article:
-
TITLE:
SPARC Expression as a Prognostic Marker in Pancreatic Ductal Adenocarcinoma
AUTHORS:
Jianxing Zhang, Peiyu Ji, Xin Fan, Xiaoyan Ma, Xuqing Wang, Zhengfa Mao
KEYWORDS:
Pancreatic Adenocarcinoma, SPARC, Prognosis, Surgery
JOURNAL NAME:
Open Journal of Gastroenterology,
Vol.8 No.4,
April
11,
2018
ABSTRACT: Background: The aim is to investigate whether secreted protein acidic and rich in cysteine (SPARC) expression could be considered as an independent prognostic factor in pancreatic ductal adenocarcinoma (PDAC). Methods: The expression of SPARC in the tumor species was detected by immunochemistry and the effect of SPARC on the prognosis was analyzed by Kaplan-Meier and Cox proportional hazard models. Results: Positive SPARC expressions recognized in tumor and stroma were 31.33% and 64.66% respectively. The expression of SPARC in stroma was closely correlated with differentiation, vascular invasion and was an indicator for predicting poor outcome after surgery in Kaplan-Meier analysis. Univariate analysis and multivariate analysis showed the following factors to be significant: perineural invasion (HR = 2.098, 95% CI: 1.144 - 3.847) and stroma positive expression of SPARC (HR = 2.120, 95% CI: 1.307 - 3.440). Conclusions: High expression of SPARC in stroma was a promising pathological marker to predict the poor outcome in patients with pancreatic ductal adenocarcinoma.
Related Articles:
-
Adetola O. Adesanya, Mfon O. Udo, Adam M. Alkali
-
Daniel Oruzio, Günter Waxenecker, Christoph Aulmann, Bruno Märkl, Theodor Wagner, Geert Mudde, Manfred Schuster, Norbert Eller, Andrea Mayer, Stefan Stranner, Gottfried Himmler, Hans Loibner, Günter Schlimok, Ralf Kircheis, Andreas Nechansky
-
Mohammed Adel Sharaf, Abdel-naby Saad Saad, Nihad Saad Abd El Motelp
-
Arthur M. Baldonado
-
Lin Jiang