TITLE:
Chemotherapy-Induced Tumour Lysis Syndrome in Gastric Adenocarcinoma with Diffuse Liver Metastases: A Case Report
AUTHORS:
Nurhan Onal Kalkan, Ayşe Oter Almalı, Azer Gokmen, Erkan Dogan
KEYWORDS:
Tumour Lysis Syndrome, Gastric Cancer, Chemotherapy, Solid Tumour
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.9 No.1,
January
17,
2018
ABSTRACT: Tumour Lysis Syndrome (TLS) is
an important oncological emergency case which
is often found together with haematological malignities and, much less often,
with solid tumours. While TLS seen in solid tumour cases usually develops
following a cytotoxic chemotherapy and its prognosis is poor. We present the
case of a 60-year-old man with gastric adenocarcinoma with diffuse liver metastases
(image shows diffuse liver metastatic lesions) and high serum LDH levels, who developed TLS after systemic
chemotherapy. With urgent and proper supportive
treatment (intravenous intensive hydration, sodium bicarbonate, diuretic, calcium gluconate, allopurinol and
haemodialysis), an impressive recovery
from TLS was achieved in the patient with an advanced stage gastric cancer.
The purpose of this report is to emphasize that although the present case was a
rare, high physician attention is required because significant morbidity or
mortality may occur when the syndrome is not duly considered during the pre-cytotoxic evaluation of the patient, when
preventive measures are not taken, or if the appropriate treatment is
not applied immediately once the syndrome appears, especially in patients who
have high tumour burden solid cancer.