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ABSTRACT: Objective: Experience of Norethisterone Tablets in the treatment of perimenopausal dysfunctional uterine bleeding, which in order to exchange experience with Clinician. Methods: 60 patients who were treated in our hospital during May 2015 to May 2016 have been diagnosed with perimenopausal dysfunctional uterine bleeding as the research object, and performed Diagnostic curettage on all patients. Then, randomly divided all the patients into two groups that every group has 30 cases. The patients in the experimental group were given Norethisterone Tablets after curettage, but the control group was given Medroxyprogesterone Acetate Tablets. Results: In the experimental group, 14 cases were cured, 11 cases were markedly effective, 3 cases were effective, and the total effective rate was 93.33%. While in the control group, 5 cases were cured, 9 cases were markedly effective, 10 cases were effective, the total effective rate was 80%. The comparison showed that the total effective rate of the two groups was different, and the difference was statistically significant (P