TITLE:
In vitro Antibacterial Efficacy of Bidens pilosa, Ageratum conyzoides and Ocimum suave Extracts against HIV/AIDS Patients’ Oral Bacteria in South-Western Uganda
AUTHORS:
Joseph Obiezu Chukwujekwu Ezeonwumelu, Muhammad Ntale, Steve Okwudili Ogbonnia, Ezera Agwu, Julius Kihdze Tanayen, Keneth Iceland Kasozi, Chukwudi Onyeka Okonkwo, Anthonia Shodunke, Ambrose Amamchukwu Akunne, Onokiojare Ephraim Dafiewhare, Jennifer Chibuogwu Ebosie, Frederick Byarugaba
KEYWORDS:
Antibacterial Efficacy, Bidens Pilosa, Ageratum Conyzoides, Ocimum Suave, Oral Bacteria, HIV/AIDS, Uganda
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.8 No.9,
September
29,
2017
ABSTRACT: The objective of the study was to determine the antibacterial efficacy of Bidens pilosa Aqueous (BPA), Bidens pilosa Ethanolic (BPE), Ageratum conyzoides Aqueous (ACA), Ageratum conyzoides Ethanolic (ACE), Ocimum suave Aqueous (OSA) and Ocimum suave Ethanolic (OSE) extracts on HIV/AIDS patients’ oral bacteria. Healthy green leaves of the plants were collected in Ishaka Uganda, processed and portions separately extracted with hot distilled water and cold ethanol. The susceptibility, MIC and MBC of each extract were determined using standard protocols. The bacteria had significant (p Bidens pilosa, Ageratum conyzoides and Ocimum suave on oral lesions of HIV/AIDS patients made by traditional healers and local people in South-Western Uganda. We recommend a detailed study of structural identities and activities of the active antibacterial principle(s) in these plants for possible new drug entities and verification of the interactive effects of the principle(s) with ARVs and cotrimoxazole used daily by HIV/AIDS patients.