TITLE:
Significance of Cu/Zn-Superoxide Dismutase Levels in Hemodialysis Patients: A Mini Review
AUTHORS:
Yuya Nakamura, Masahiro Inagaki, Sachiyo Kenmotsu, Shiho Yamadera, Isao Ohsawa, Hiromichi Gotoh, Yoshikazu Goto, Naoki Sato, Tatsunori Oguchi, Mayumi Tsuji, Yuji Kiuchi
KEYWORDS:
Cu/Zn-Superoxide Dismutase, Hemodialysis, Complex Marker
JOURNAL NAME:
Modern Research in Inflammation,
Vol.6 No.2,
May
30,
2017
ABSTRACT:
Cu/Zn-superoxide dismutase (Cu/Zn-SOD) is an enzyme that is ubiquitously
present in the cytoplasm and causes dismutation of superoxide radicals,
therefore Cu/Zn-SOD is primarily used as an antioxidant marker. Levels of
Cu/Zn-SOD are higher in the serum of hemodialysis patients than in serum of
healthy volunteers. The increase of serum Cu/Zn-SOD levels is related to the
decrease of kidney function with aging and arteriosclerosis in hemodialysis
patients. Moreover, infection, vascular puncture, and hemostasis may be related
to the increase in serum Cu/Zn-SOD levels. As it is associated with numerous
factors in hemodialysis patients, Cu/Zn-SOD may serve as a complex
marker for arteriosclerosis, vascular, and inflammatory conditions. It is important
to investigate various agents that decrease serum Cu/Zn-SOD levels to
improve the life-span of hemodialysis patients.