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https://doi.org/10.1016/j.juro.2012.10.071

has been cited by the following article:

• TITLE: World’s First Myoblast Treatment of Human Cancer Found Safe and Efficacious

  AUTHORS: Peter K. Law, Shi Jun Song, Ping Lu, Yong Gao, Mingzhang Ao, Hongdan Zhao, Liyun Bai, Kang Guo, Danlin M. Law

  KEYWORDS: Human Cancer Treatment, Tumor Shrinkage, Cancer Apoptosis, Metastasis Inhibition, Cancer Clinical Trial, TNF-α, Myoblasts, Myotubes, Nude Mice, Cell Therapy

  JOURNAL NAME: Open Journal of Regenerative Medicine, Vol.6 No.1, March 31, 2017

  ABSTRACT: Evolution of placental mammals over the past 160 million years witnesses the relative sparing of muscles from cancer attacks. In 1) nude mice with human gastrointestinal or lung tumors, and 2) human subjects with liver, lung or gastrointestinal tumors, intra-tumor implantation of allogeneic human myoblasts induced cancer apoptosis, inhibiting metastasis and tumor growth. We postulate four mechanisms of cancer apoptosis: a) myoblasts releasing tumor necrosis factor-α (TNF-α); b) deprivation of nutrients and oxygen; c) local inflammatory and immunologic attacks; and d) prevention from metastasis. These basic and clinical studies demonstrated preliminary safety and efficacy of intra-tumor myoblast implantation in the development of prevention and treatment for cancer, now the number one disease killer of mankind.