TITLE:
Cell-Cycle-Associated Amplified Genomic-DNA Fragments (CAGFs) Might Be Involved in Chloroquine Action and Resistance in Plasmodium falciparum
AUTHORS:
Gao-De Li
KEYWORDS:
Plasmodium falciparum, Chloroquine Resistance, Cell-Cycle-Associated Amplified Genomic-DNA Fragment (CAGF), Plasmodium falciparum Cystine Transporter (Pfct), Glutathione (GSH), Reactive Oxygen Species (ROS), Pfcrmp
JOURNAL NAME:
Open Access Library Journal,
Vol.4 No.3,
March
14,
2017
ABSTRACT:
As
a cheap and safe antimalarial agent, chloroquine (CQ) has been used in the battle against malaria for more than half century.
However, the mechanism of CQ action and resistance in Plasmodium falciparum remains elusive. Based on further analysis of our published experimental results, we propose that
the mechanism of CQ action and resistance
might be closely linked with cell-cycle-associated amplified genomic-DNA fragments
(CAGFs, singular form = CAGF) as CQ induces CAGF
production in P. falciparum, which
could affect multiple biological processes of the parasite, and thus might
contribute to parasite death and CQ resistance. Recently, we found that CQ
induced one of CAGFs, UB1-CAGF, might downregulate a probable P. falciparum cystine transporter
(Pfct) gene expression, which could be used to understand the mechanism of CQ
action and resistance in P. falciparum.