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has been cited by the following article:

• TITLE: The Risk of Islet Cell and Insulin Autoantibodies and Their Predictive Strength as Markers of Type-1 Diabetes in a Cross-Section of Nigerian Population

  AUTHORS: Babatunde Ishola Adejumo, Uchechukwu Dimkpa, Chinwe Obianuju Ewenighi, Alaba Micheal Emmanuel, Uche Cletus Odionyenma, Gregory Ashimedua Uchuno, Kingsley Ifeanyi Omosor, Festus Idiayuwaru Aghedo

  KEYWORDS: Type-1 Diabetes, IAA, ICA, Autoimmune Marker, Edo State

  JOURNAL NAME: Health, Vol.8 No.12, September 9, 2016

  ABSTRACT: Aim: We demonstrated the risk of developing islet autoantibodies-Insulin Autoanti-bodies (IAAs) and Islets cell Autoantibodies (ICAs)-in type-1 diabetic relatives and newly diagnosed type-1 patients compared to non-diabetic controls. We also aimed to determine the predictive strengths of both autoantibodies in the development of type-1 diabetes mellitus, and which of the two autoantibodies is a better predictive marker of type-1 diabetes mellitus among Nigerian adults. Methodology: A total number of four hundred and fifty five (455) subjects (211 (46%) males, and 244 (54%) females) aged between 35 - 76 years were recruited for the study. IAA and ICA levels were estimated using ELISA reagents from Biomerica Inc. Other parameters such as fasting blood sugar, urine glucose, and urine protein were assessed using standard biochemical techniques. Results: Relatives of type-1 diabetic patients and newly diagnosed type-1 diabetic patients were at greater risk (p