TITLE:
Relevant Frequency of Multiple Infections with High- and Low-Risk HPV Genotypes among Mexican Women Attending a Tertiary Care Hospital
AUTHORS:
Saúl Flores-Medina, Carmen S. García-Romero, Diana M. Soriano-Becerril, Francisco J. Díaz-García, Silvia Giono-Cerezo, Graciela Castro-Escarpulli
KEYWORDS:
Human Papillomavirus, High-Risk Genotypes, HPV Co-Infections, Linear Array Genotyping
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.6 No.7,
June
17,
2016
ABSTRACT: Aims: To assess the frequency and the main HPV genotypes circulating
among a group of women attending at a third level Hospital in Mexico City.
Methods: A cross-sectional and descriptive study was performed in a group of
143 female outpatients of the Gynecology and Obstetrics Service at the National
Institute of Perinatology of Mexico. Cervical swabs were taken from
participants and subjected to simultaneous detection/genotyping of HPV by
Linear Array Genotyping Test (Roche Molecular Systems). Mann-Whitney U, median
and/or Square Chi tests were used to compare socio-demographical features
between HPV-infected and uninfected women. Results: A total of 66 women (46.2%)
had HPV infection. Overall, 112 genotypes were detected either as single
infections (45.5%) or multiple genotype infections (54.5%). The cumulated
frequency of multiple infections with high-/low- and high-/high-risk HPV
genotypes was 63.9 %. The most frequent high-risk genotypes were HPV52 HPV58
and HPV51, whereas the most frequent low-risk genotypes were HPV6, HPV53 and
HPV84. Infected women were significantly younger and have less stable partner
relationships than uninfected women (p