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Article citations


Kim, W.Y. and Sharpless, N.E. (2006) The Regulation of INK4/ARF in Cancer and Aging. Cell, 127, 265-275.

has been cited by the following article:

  • TITLE: Immunohistochemical Analysis of p16 Expression in Uterine Smooth Muscle Tumors

    AUTHORS: Seiji Kanayama, Hidekazu Oi, Ryuji Kawaguchi, Naoto Furukawa, Hiroshi Kobayashi

    KEYWORDS: Leiomyoma, Leiomyosarcomas, p16, Smooth Muscle Tumors, STUMP

    JOURNAL NAME: Open Journal of Obstetrics and Gynecology, Vol.5 No.12, October 7, 2015

    ABSTRACT: Objective: Immunohistochemistry with p16 antibody is used as a diagnostic marker in several gynecologic pathologies. The purpose of the present study was to evaluate the diagnostic and prognostic significance of p16 immunohistochemistry in various uterine smooth muscle tumors. Methods: Tissue specimens, including 29 leiomyomas, 13 smooth muscle tumors of uncertain malignant potential (STUMP), and 17 leiomyosarcomas, were obtained from 59 patients with uterine smooth muscle tumors. The prevalence of p16 expression in various uterine smooth muscle tumors was examined using immunohistochemistry methods and we investigated the association between p16 expression and various clinicopathologic parameters, including prognosis of leiomyosarcomas. Results: The prevalence of p16 expression of leiomyomas, STUMP, and leiomyosarcomas tumors was 10.3%, 38.4%, and 76.4%, respectively. The prevalence and immunohistochemistry scores of p16 were significantly higher in the leiomyosarcomas group than in the leiomyomas or STUMP tumor groups. In the leiomyosarcomas groups, p16 immunohistochemistry scores were significantly higher in the groups with more advanced stage, higher mitotic activity, and recurrence. The relationship among p16 immunohistochemistry scores and age, tumor size, extent of necrosis, and degree of myometrial invasion was not significant. High expression of p16 in leiomyosarcomas was linked to shorter disease-free and overall survival. Conclusions: The use of p16 immunohisitochemistry is a useful marker in differential diagnosis in various uterine smooth muscle tumors. Moreover, p16 overexpression possibly plays an important role in tumor progression and we demonstrate that p16 may be a predictor of overall survival in patients with leiomyosarcoma tumors.