TITLE:
Natural ECM-Bacterial Cellulose Wound Healing—Dubai Study
AUTHORS:
Safwat Mohd. El-Hoseny, Pierre Basmaji, Gabriel Molina de Olyveira, Ligia Maria Manzine Costa, Abdulwahid M. Alwahedi, José Domingos da Costa Oliveira, Gino Bruno Francozo
KEYWORDS:
Bacterial Cellulose (Nanoskin), Natural Nanocomposites, Regenerative Medicine, Stem Cells
JOURNAL NAME:
Journal of Biomaterials and Nanobiotechnology,
Vol.6 No.4,
September
16,
2015
ABSTRACT: Bacterial cellulose (BC) can be used in wide area of applied scientific, especially for tissue regeneration
and regenerative medicine, lately, bacterial cellulose mats are used in the treatment of skin
conditions such as burns and ulcers, because of the morphology of fibrous biopolymers serving as
a support for cell proliferation, its pores allow gas exchange between the organism and the environment.
Moreover, the nanostructure and morphological similarities with collagen make BC attractive
for cell immobilization, cell support and Natural Extracellular Matrix (ECM) Scaffolds. In
this scope, Natural ECM is the ideal biological scaffold since it contains all the components of the
tissue. The development of mimicking biomaterials and hybrid biomaterial can further advance
directed cellular differentiation without specific induction. The extracellular matrix (ECM) contains
several signals that are received by cell surface receptors and contribute to cell adhesion and
cell fate which control cellular activities such as proliferation, migration and differentiation. As
such, regenerative medicine studies often rely on mimicking the natural ECM to promote the formation
of new tissue by host cells, and characterization of natural ECM components is vital for the
development of new biomimetic approaches. In this work, the bacterial cellulose fermentation
process is modified by the addition of vegetal stem cell to the culture medium and natural materials
before the bacteria are inoculated. In vivo behavior using natural ECM for regenerative medicine
is presented.