TITLE:
Vaginal Intraepithelial Neoplasia Detected with Cervical Liquid-Based Cytology: Old Concerns or New Facilities?
AUTHORS:
Mariana Camezim Beldi, Maricy Tacla, Marcia Farina Kamilos, Fabiane Sarmanho, Alexandre Ab’Saber, Sheila Siqueira, Venancio Avancini Ferreira Alves, Edmundo C. Baracat, Adhemar Longatto-Filho
KEYWORDS:
Liquid-Based Cytology, Cervical Screening, VAIN, HPV Induced Lesions, Vaginal
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.5 No.11,
September
14,
2015
ABSTRACT: Background: The detection of vaginal intraepithelial neoplasia (VAIN) in
cervical samples is not a common finding. Therefore, we aimed to report VAINs
detected in liquid-based cytology (LBC) from women examined at Hospital das
Clínicas of Faculty of Medicine, Sao Paulo State University. Materials and
Methods: We evaluated LBC samples from women referred to gynecology examination
for different reasons (previous abnormal PapTest, follow up of treated cervical
lesion, ecc) and women examined for regular screening proposals, and compared
with biopsy diagnoses, including the controversial diagnoses of vaginal
intraepithelial neoplasia (VAIN). Results: From 1866 patients, 1423 (76.3%)
cases were negative and 443 (23.7%) were positive for any cellular alteration.
Age of patients ranged from 12 to 86 years. We detected 25 histologically
confirmed VAIN (1.3% p = 0.0002 by Fisher’s exact test
IC 95% 0.0090 - 0.0198) and 1.1% VAIN (p = 0.0031 by Fisher’s exact test IC 95%
0.0077 - 0.0179). Conclusion: The identification of VAIN in routine is
feasible; the professionals involved with cytological examination should be
aware of these lesions in Pap test samples.