TITLE:
Use of Mesenchymal Stem Cells to Grow Cartilage and Bone
AUTHORS:
Hosseyn Rafei
KEYWORDS:
Mesenchymal Stem Cells, Cartilage, Bone, Embryonic Sources
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.6 No.6,
June
23,
2015
ABSTRACT: Regardless of the fact that
bones have a tremendous capacity to be repaired, there are various clinical
situations where allographs seek to enhance the regeneration of bones through
promotion of osteogenesis [1]. Precarious botches linked to the present
grafting treatments include osteonecrosis along with restricted combination
between the grafted and host tissues. It is considered that the fundamental
issue with the present approaches to bone grafting is the fact that they lead
to bone regeneration by means of direct osteogenesis. Therefore, it may be
hypothesized that the use of cartilage in the promotion of endochondral
regeneration of bones may leverage normal development and repair sequences resulting
in a properly vascularized regenerate capable of integrating with the host
tissues. Various tests have demonstrated that cartilage grafts are able to
support the regeneration of vascularized and integrated bone tissues in vivo, while lineage tracing
experiments have revealed graft derived regenerates.