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http://dx.doi.org/10.1016/j.dld.2010.12.016

has been cited by the following article:

• TITLE: Diarrhea and Hypokalemic Rhabdomyolysis Due to Apoptotic Colitis as the Initial Manifestation of Common-Variable Immunodeficiency in an Adolescent

  AUTHORS: David Green, Nina Dave, Hua Liu, Charu Subramony, Michael J. Nowicki

  KEYWORDS: Apoptotic Colitis, Common-Variable Immune Deficiency, Hypokalemia, Rhabdomyolysis

  JOURNAL NAME: Open Journal of Pediatrics, Vol.4 No.2, May 22, 2014

  ABSTRACT: We present the case of an adolescent who presented with rhabdomyolysis due to severe hypokalemia arising from chronic diarrhea. Initial evaluation for celiac disease, known to present in this manner, was negative. Further evaluation with colonoscopy showed a normal appearing colon but biopsies showed a significant number of apoptotic cells in the mucosal crypts supporting a diagnosis of apoptotic colitis. Investigation into the cause of apoptotic colitis resulted in a diagnosis of common variable immune deficiency due to a defect in the inducible T-cell costimulator (ICOS) gene. Physicians should be aware of this uncommon condition and the importance of mucosal biopsy despite the presence of normal appearing mucosa.