TITLE:
Mechanisms of change contraction of function of the muscles in vitro at allergic
AUTHORS:
Alexander Y. Teplov, Albert M. Farkhutdinov, Vladimir I. Torshin
KEYWORDS:
Skeletal Muscle; Contraction Characteristics; Extensor Digitorum Longus; Soleus; Diaphragm; Non-Quantum Secretion; Protein Sensitization
JOURNAL NAME:
Health,
Vol.6 No.5,
February
24,
2014
ABSTRACT: In
this work, mechanisms of influence of protein sensibility of an organism on
contractile function of the isolated skeletal muscles of the mouse—“fast”—musculus extensor digitorum longus, “mixed”—musculus diaphragma and “slow”— musculus soleus are investigated. It is shown that at a protein sensitization all “fast”, “mixed” and “slow” skeletal muscles change the contractile properties. The vector of these changes for muscles with a various
phenotypes carries opposite character. Force
of the reduction caused carbacholine at a “slow” and “mixed” muscles increase, at “fast”—decreases. A vector of change of force of
reduction on carbacholine at protein sensitization at these skeletal muscles correlates with changes of non-quantum secretion acetylcholine in a zone of a trailer plate. Opposite changes of functional properties of “fast”
and “mixed” muscles and “slow” muscles of a shin of the
mouse at protein sensitization are
caused by dynamics cholinoceptive processes of excitation of membrane muscular fibers. It comes out with the
assumption, that change of the contraction functions of skeletal muscles at
protein sensitization is caused by changes of cholinoceptive processes of excitation of a membrane of muscular fibers, and other changes in system of electro-mechanical
interface.