Objective: To establish a new intervention for patients with SD, namely, GPI by TCM, from the perspective of yin-yang syndrome differentiation and evaluate its efficacy by random sampling. Methods: Based on cluster random sampling, 517 subjects were tested by Centre for Epidemiological Studies Depression Scale (CES-D) and Hamihon Rating Scale for Depression (HAMD-17). After the screening, 239 subjects were included into the study. Then, 72 subjects were chosen randomly and divided into two groups: Intervention group and control group. Before the intervention, the subjects were tested by CES-D. After the intervention (8 weeks later), the subjected were tested by CES-D again. All the data were analyzed by T-test and Rank sum test. Results: There were significant statistical differences between the total scores of the intervention group before and after the intervention, and between the total scores of the intervention group and control group after the intervention. Conclusions: GPI by TCM, which is based on supporting yang to inhibit yin, has desirable effects on alleviating the negative mood of patients with SD.