Does conventional phototherapy have any effect on platelet count in full term neonates with indirect hyperbilirubinemia?
Alireza Monsef, Fatemeh Eghbalian
DOI: 10.4236/health.2011.312119   PDF    HTML     6,733 Downloads   11,395 Views   Citations


This study evaluates the platelet count changes in neonates with hyperbillirubinemia who received phototherapy. In this Prospective Descriptive-cross sectional study 144 full term newborns with indirect hyperbillirubinemia who received phototherapy in neonatal ward of Bessat hospital in Hamedan province of Iran were studied from September 2007 to February 2008 for evaluation the effect of phototherapy on platelet count. The platelet had counted by cell counter and it had controlled by slide platelet counting. The data were analyzed using spss version. 13 and compared with paired-samples T test. 58 neonates (40.3%) were boys and 86 (59.7%) were girls. The mean age of neonates was 7.04 +/– 5.49 days (2 - 29 days). The mean (± SD) platelet counts were 287833.3 + 92332.4 before and 299444.4 + 98565.2 after phototherapy. Analysis of data with paired T test showed significant difference in platelet count before and after phototherapy. Mean platelet count after phototherapy was higher than that before treatment. The study had propounded that mean platelet count increased with extended mean phototherapy time. This study had propounded this hypothesis that phototherapy in full term icteric newborns leads to increased platelet count. It may be due to accelerated platelet turnover in peripheral microvasculature with adequate platelet reserve.

Share and Cite:

Monsef, A. and Eghbalian, F. (2011) Does conventional phototherapy have any effect on platelet count in full term neonates with indirect hyperbilirubinemia?. Health, 3, 709-711. doi: 10.4236/health.2011.312119.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Kleigman, R. and Jaundice, N. (2007) In: Behrman, R.E., Kliegman, R.M. and Jenson, H.B., Eds., Nelson Textbook of Pediatrics, 17th Edition, Saunders, Philadelphia, 753-766.
[2] Wong, R., Gllen, H. and Sibley, D. (2006) Therapy for unconjugated hyperbilirubinmia. Fanaroff & Martin’s Neonatal Prenatal Medicine, 8th Edition, Saunders, Philadelphia, 1419-1427 and 1440-1445.
[3] Eghbalian, F. (2003) Phototherapy and hyperbilirubinemia. In: Eghbalian, F., Ed., Neonatal Jaundice, 1st Edition, Hamadan University of Medical Sciences, Hamadan, 33-50.
[4] Maisels, J. and Watchko, J. (2000) Phototherapy in neonatal jaundice. 11th Edition, Harwood Academic Publishers, New York, 177-199.
[5] Johnson, L., Brown, A. and Bhutani, V. (2002) System-based approach to management of neonatal jaundice and prevention of kernicterous. Journal of Pediatrics, 140, 386-397. doi:10.1067/mpd.2002.123098
[6] Karim, M., Clelland, I. and Chapman, I. (1981) Beta-thromboglobulin levels in plasma of jaundiced neonates exposed to phototherapy. Journal of Perinatal Medicine, 9, 141-144. doi:10.1515/jpme.1981.9.3.141
[7] Sakha, K. and Soltani, A. (2007) Effect of phototherapy on platelet and leukocyte count in hyperbilirubinemic neonates. Journal of Tabriz University of Medical Science, 28, 59-62.
[8] Pishva, N. and Pishva, H. (2000) Incidence of thrombocytopenia in hyperbilirubinemic neonates during phototherapy. Acta Medica Iranica, 38, 7-9.
[9] Maurer, H., Haggins, J. and Still, W. (1976) Platelet injury during phototherapy. American Journal of Hematology, 1, 89-96. doi:10.1002/ajh.2830010110
[10] Nathan, D. and Oski, F. (1998) Hematology of infancy and childhood. 15th Edition, Saunders, Philadelphia, 125-127.
[11] Zieve, P. and Solomen, M. (1966) The effect of hematoporphyrin and light on human platelets. Journal of Cellular Physiology, 67, 281-284.
[12] Christensen, R. (2000) Hematologic problems of the neonates. 1st Edition, Saunders, Philadelphia, 296-310.
[13] Maurer, H., Fratkin, M., McWilliams, N., et al. (1976) Effects of phototherapy on platelet count in low birth weight infants and on platelet production and life span in rabbits. Pediatrics, 57, 506-512.
[14] Tzziciancarelli, M., Amicosante, G. and Menichelli, A. (1985) Photodynamic damage induced by bilirubin on human platelets: Possible relevance to newborn pathology. Biology of the Neonate, 48, 336-340. doi:10.1159/000242190

Copyright © 2024 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.