Immunopotentiating Activity of Dendrobium Species in Mouse Splenocytes
David T. W. Lau, Michel K. T. Poon, Hoi Yan Leung, Kam Ming Ko
DOI: 10.4236/cm.2011.23017   PDF    HTML     5,697 Downloads   10,197 Views   Citations


This study aimed to explore a pharmacological activity marker for quality assurance of Dendrobium species. The immunopotentiating activity in aqueous extracts prepared from four Dendrobium species, including D. officinalis, was assessed by an in vitro assay of concanavalin A (Con A)-stimulated proliferation of mouse splenocytes. Four samples of commercially available Dendrobii Caulis were also analyzed for comparison. The results indicated that the aqueous extract of D. officinalis produced immunopotentiating action, as evidenced by the increase in Con A-stimulated proliferation of mouse splenocytes, with the extent of stimulation being more prominent than those of other tested Dendrobium species and Dendrobii Caulis samples. In conclusion, an in vitro immunopotentiation assay may be used for assessing the pharmacological activity of Dendrobium species. The finding that D. officinalis produced a more potent immunopotentiating action is consistent with its "yin-nourishing" action in Chinese medicine, which is more effective than other Dendrobium species in clinical use.

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D. Lau, M. Poon, H. Leung and K. Ko, "Immunopotentiating Activity of Dendrobium Species in Mouse Splenocytes," Chinese Medicine, Vol. 2 No. 3, 2011, pp. 103-108. doi: 10.4236/cm.2011.23017.

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The authors declare no conflicts of interest.


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