Enzyme Kinetic Equations of Irreversible and Reversible Reactions in Metabolism


This paper compares the irreversible and reversible rate equations from several uni-uni kinetic mechanisms (Michaelis-Menten, Hill and Adair equations) and bi-bi mechanisms (single- and double- displacement equations). In reversible reactions, Haldane relationship is considered to be identical for all mechanisms considered and reversible equations can be also obtained from this rela- tionship. Some reversible reactions of the metabolism are also presented, with their equilibrium constant.

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Imperial, S. and Centelles, J. (2014) Enzyme Kinetic Equations of Irreversible and Reversible Reactions in Metabolism. Journal of Biosciences and Medicines, 2, 24-29. doi: 10.4236/jbm.2014.24005.

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The authors declare no conflicts of interest.


[1] Alberty, R.A., Cornish-Bowden, A., Goldberg, R.N., Hammes, G.G., Tipton, K. and Westerhoff, H.V. (2011) Reccommendations for Terminology and Databases for Biochemical Thermodynamics. Biophysical Chemistry, 155, 89- 103. http://dx.doi.org/10.1016/j.bpc.2011.03.007
[2] Hofmeyr, J.-H.S. and Cornish-Bowden, A. (1997) The Reversible Hill Equation: How to Incorporate Cooperative Enzymes into Metabolic Models. CABIOS, 13, 377-385.
[3] King, E.L. and Altman, C. (1956) A Schematic Method of Deriving the Rate Laws for Enzyme-Catalyzed Reactions. The Journal of Physical Chemistry, 60, 1373-1378. http://biokin.com/king-altman/index.html http://dx.doi.org/10.1021/j150544a010
[4] Barman, T.E. (1969) Enzyme Handbook. Springer-Verlag, Berlin. http://dx.doi.org/10.1007/978-3-642-86602-9

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