Primary Pupillary Margin Cyst of the Iris Pigment Epithelium
R. Dammacco, G. Giancipoli, S. Guerriero, D. Piscitelli, N. Cardascia
DOI: 10.4236/cm.2011.21003   PDF    HTML     6,170 Downloads   11,814 Views   Citations


Purpose: Description of a patient with a solitary cyst of the pupillary margin iris pigment epithelium (IPE). Methods: A 63-year-old man referred a suspected iris-ciliary body melanoma in his left eye. Based on both clinical examination and ultrasound biomicroscopy, melanoma was considered unlikely. Surgery was under-taken to correct recurrent deterioration of vision due to movement of the lesion across the visual axis. Results: The lesion was excised completely. Ultrasound biomicroscopy and histopathological examination ruled out melanoma and allowed a final diagnosis of primary pupillary margin cyst of the IPE, characterized of pig-mented epithelium, with no connective tissue or vessels. No recurrences or fresh lesions appeared during a one-year follow-up. Conclusions: Primary epithelial iris cysts are usually benign. Treatment is required only in symptomatic patients and those with an uncertain diagnosis. Ultrasound biomicroscopy is indispensable to confirm the clinical diagnosis, follow the clinical course and intervene if surgery is required.

Share and Cite:

Dammacco, R. , Giancipoli, G. , Guerriero, S. , Piscitelli, D. and Cardascia, N. (2011) Primary Pupillary Margin Cyst of the Iris Pigment Epithelium. Chinese Medicine, 2, 16-19. doi: 10.4236/cm.2011.21003.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] J. A. Shields, “Primary Cysts of the Iris,” Transactions of the American Ophthalmological Society, 1981, Vol. 79, pp. 771-809.
[2] C. Auw-Haedrich, G. Schlunck and H. Witschel, “Primary Iris Stromal Cyst with Unusual Symptoms in an Adult,” klinische Monatsbl?tter für Augenheilkunde, 2000, Vol. 216, pp. 420-423. Doi:10.1055/s-2000-10589
[3] T. Hildreth, J. Maino and T. Hartong, “Primary and Secondary Iris Cysts,” Journal of the American Optometric Association, 1991, Vol. 62, pp. 588-592.
[4] H. Tanihara, J. Akita, M. Honjo and Y. Honda, “Angle Closure Caused by Multiple, Bilateral Iridociliary Cysts,” Acta Ophthalmologica Scandinavica, 1997, Vol. 75, No. 2, pp. 216-217. Doi:10.1111/j.1600-0420.1997.tb00128.x
[5] N. Lois, C. L. Shields, J. A. Shields and G. Mercado, “Primary Cysts of the Iris Pigment Epithelium. Clinical Features and Natural Course in 234 Patients,” Ophthalmology, 1998, Vol. 105, No. 10, pp. 1879-1885. Doi:10.1016/S0161-6420(98)91034-X
[6] P. A. Chandler and H. E. Braconier, “Spontaneous Intra-Epithelial Cysts of Iris and Ciliary Body with Glaucoma,” 1958, Vol. 45(4 Pt II), pp. 64-74.
[7] A. Vela, J. C. Rieser and D. G. Campbell, “The Heredity and Treatment of Angle-Closure Glaucoma Secondary to Iris and Ciliary Body Cysts,” Ophthalmology, 1983, Vol. 91, No. 4, pp. 332-337.
[8] A. Azuara-Blanco, G. L. Spaeth, S. V. Araujo, J. J. Augsburger and A. K. Terebuh, “Plateau Iris Syndrome Associated with Multiple Ciliary Body Cysts : Report of 3 Cases,” Archives of Ophthalmology, 1996, Vol. 114, No. 6, pp. 666-668.
[9] W. L. M. Alward and K. C. Ossoinig, “Pigment Dispersion Secondary to Cysts of the Iris Pigment Epithelium,” Archives of ophthalmology, 1995, Vol. 113, No.12, pp. 1574-1575.
[10] A. Cowan, “Congenital and Familial Cysts and Flocculi of the Iris,” American Journal of Ophthalmology, 1936. Vol. 19, pp. 287-291.
[11] R. A. Lewis and L. M. Merin, “Iris Flocculi and Familial Aortic Dissection,” Archives of ophthalmology, 1995, Vol. 113, pp. 1330-1331.
[12] F. B. Sallo and I. Hatvani, “Recurring Transitory Blindness Caused by Primary Marginal Pigment Epithelial Iris Cysts,” American Journal of Ophthalmology, 2002, Vol. 133, No. 3, pp. 407-409. Doi:10.1016/S0002-9394(01)01332-0
[13] M. Yanoff and L. E. Zimmerman, “Pseudomelanoma of Anterior Chamber Caused by Implantation of Iris Pigment Epithelium,” Archives of ophthalmology, 1965, Vol. 74, No. 3, pp. 302-305.
[14] K. Kawaguchi, S. Yamamoto, Y. Nagae, A. Okada, N. Iwasaki and Y. Tano, “Treatment of Recurrent Giant Iris Cyst with Intracyst Administration of Mitomycin C,” British Journal of Ophthalmology, 2000, Vol. 84, No. 7, pp. 800-801. Doi:10.1136/bjo.84.7.799b
[15] J. C. Tsai, E. L Arrindell, D. M. O’Day, “Needle Aspiration and Endodiathermy Treatment of Epithelial Inclusion Cyst of the Iris,” American Journal of Ophthalmology, 2001, Vol. 131, No. 2, pp. 263-265. Doi:10.1016/S0002-9394(00)00707-8
[16] J. Kuchenbecker, M. Motschmann, K. Schmitz and W. Behrens-Baumann, “Laser Iridocystotomy for Bilateral Acute Angle-Closure Glaucoma Secondary to Iris Cysts,” American Journal of Ophthalmology, 2000, Vol. 129, No. 3, pp. 391-393. Doi:10.1016/S0002-9394(99)00392-X
[17] H. F. ?ner, S. Kaynak, N. Ko?ak and G. ?ingil, “Management of Free Floating Iris Cysts in the Anterior Chamber: A Case Report,” European Journal of Ophthalmology, 2003, Vol. 13, No. 2, pp. 212-214.
[18] M. Baykara, S. Sahin and H. Ertürk, “Free Iris Cyst in the Anterior Chamber,” Ophthalmic Surgery Lasers and Imaging , 2004, Vol. 35, No. 1, pp. 74-75.
[19] L. Verma, P. Venkatesh, S. Sen, N. C. Lakshmaiah and H. K. Tewari, “Surgical Removal of a Free Floating Cyst of the Iris Pigment Epithelium Causing Disturbing Visual Symptoms,” Ophthalmic surgery and lasers, 1999, Vol. 30, No. 3, pp. 223-225.

Copyright © 2024 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.