Prospective Memory Assessment, before and after the Use of Concentrated Extract of Soy, in Postmenopausal Women Complaining of Memory Impairment


Objective: To evaluate the performance of a sample of postmenopausal women complaining of decline of prospective memory, undergoing therapy with concentrated extract of soy (CES) for six months, through specific neuropsychological assessment, developed for this purpose. Materials and Methods: A randomized and double-blind study was with 90 women, 12-month amenorrhea, 40 years to 65 years and body mass index (BMI) above 30 kg/m2, whose complaints were reduction of cognitive efficiency. The participants were randomly divided into two treatment groups: Group I received one capsule of 150 mg extract of soy, with 60 mg isoflavones orally/day; Group IIreceived one capsule placebo, for six months. All participants underwent a detailed interview, the MMSE, depression scale, and as they were being included in the study, self-perception scales and neuropsychological tests before and after six months of treatment. For analysis purposes, we applied the ANOVA and t-student tests. Results: Our results suggest a possible positive effect regarding the improvement in verbal fluency and executive function tasks of planning and mental flexibility, in women undergoing therapy with concentrated extract of soy in postmenopause. There was no correlation between prospective memory and cognitive performance, and there were only intensity scores of the depressive symptoms. Conclusion: Isoflavones act favorably on the cognitive function, amongst all functions, only on verbal memory and executive function tasks of planning and mental flexibility. The others showed no signs of improvement. We concluded that concentrated extract acts only on some cognitive functions.

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L. Laprano Vieira, T. Embiruçu de Araújo, M. Haidar and I. Silva, "Prospective Memory Assessment, before and after the Use of Concentrated Extract of Soy, in Postmenopausal Women Complaining of Memory Impairment," Neuroscience and Medicine, Vol. 4 No. 4, 2013, pp. 217-222. doi: 10.4236/nm.2013.44034.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] A. M. Fonseca and H. W. Halbe, “Fisiologia do Climatério,” In: Tratado de Ginecologia, 2nd Edition, Roca, São Paulo, 1994, pp. 1237-1242.
[2] C. E. Fernandes, E. C. Baracat and G. R. Lima, “Climatério: Manual de Orientação da FEBRASGO,” Ponto, São Paulo, 2004.
[3] E. C. Baracat and G. R. Lima, “Climatério in: Ginecologia—Manuais, Guia de Medicina Ambulatorial e Hospitalar,” Manole, São Paulo, 2005, pp. 339-343.
[4] I. Silva, G. Mor and F. Naftolin, “Estrogen and the Aging Brain,” Maturitas, Vol. 38, No. 1, 2001, pp. 95-100.
[5] A. O. Pedro, A. M. Pinto-Neto, L. Costa-Palva, M. J. Osis and E. Hardy, “Procura de Serviço Médico por Mulheres Climatéricas Brasileiras,” Revista de Saúde Pública, Vol. 36, No. 4, 2002, pp. 484-490.
[6] E. W. Freeman, M. D. Sammel, H. Lin and D. B. Nelson, “Associations of Hormones and Menopausal Status with Depressed Mood in Women with No History of Depression,” Archives of General Psychiatry, Vol. 63, No. 4, 2006, pp. 375-382.
[7] A. C. J. S. Silva and M. F. S. Sá, “Efeito dos Esteróides Sexuais Sobre o Humor e a Cognião,” Revisão da literatura. Revista de Psiquiatria Clínica, Vol. 33, No. 2, 2006, pp. 60-67.
[8] D. Benites and W. B. Gomes, “Translation, Adaptation and Preliminary Validation from Prospective and Retrospective Memory Questionnalre (PRMQ),” PsicoUSF, Vol. 12, No. 1, 2007, pp. 45-54.
[9] S. Mizuno, “Prospective Memory for Future Intentions,” Bulletin of Toyo Gakuen University, Vol. 9, No. 1, 2001, pp. 1-11.
[10] P. S. Bisiacchi, V. Tarantino and A. Ciccola, “Aging and Prospective Memory: The Role of Working Memory and Monitoring Processes,” Aging Clinical and Experimental Research, Vol. 20, No. 6, 2008, pp. 569-577.
[11] C. Kaari, M. A. Haidar, J. M. Soares Júnior, M. G. Nunes, L. G. Quadros and C. Kemp, “Randomized Clinical Trial Comparing Conjugated Equine Estrogens and Isoflavones in Postmenopausal Women: A Pilot Study,” Maturitas, Vol. 53, No. 1, 2006, pp. 49-58.
[12] J. Miquel, A. Ramírez Boscá, J. V. Ramírez-Boscá and J. D. Alperi, “Menopause: A Review on the Role of Oxygen Stress and Favorable Effects of Dietary Antioxidants,” Archives of Gerontology and Geriatrics, Vol. 42, No. 3, 2006, pp. 289-306.
[13] G. Cheng, B. Wilczek, M. Warner, J. A. Gustafsson and B. M. Landgren, “Isoflavone Treatment for Acute Menopausal Symptoms,” Menopause, Vol. 14, No. 3, 2007, pp. 468-473.
[14] A. L. MacReady, O. B. Kennedy, J. A. Ellis, C. M. Williams, J. P. E. Spencer and L. T. Butler, “Flavonoids and Cognitive Function: A Review of Human Randomized Controlled Trial Studies and Recommendations for Future Studies,” Genes & Nutrition, Vol. 4, No. 4, 2009, pp. 227-242.
[15] T. H. Crook, E. P. Feher and G. J. Larrabee, “Assessment of Memory Complaints in Age Associated Memory Impairment: The MAC-Q,” International Psychogeriatrics, Vol. 4, No. 2, 1992, pp. 165-176.
[16] R. Norbury, W. L. Cutter, J. Compton, D. M. Robertson, M. Craig, et al., “The Neuroprotective Effects of Estrogen on the Aging Brain,” Experimental Gerontology, Vol. 38, No. 1-2, 2003, pp. 109-117.
[17] D. Kritz-Silverstein, D. Von Muhlen, E. Barret-Connor and M. A. B. Bressel, “Isoflavones and Cognitive Function in Older Women: The Soy and Postmenopausal Health in Aging (SOPHIA) Study,” Menopause, Vol. 10, No. 3, 2003, pp. 196-202.
[18] S. E. File, D. E. Hartley, S. Elsabagh, R. Duffy and H. Wiseman, “Cognitive Improvement after 6 Weeks of Soy Supplements in Postmenopausal Women Is Limited to Frontal Lobe Function,” Menopause, Vol. 12, No. 2, 2005, pp. 193-201.
[19] H. Hachul, L. R. A. Bittencourt, J. M. Soares Jr., S. Tufik and E. C. Baracat, “Sleep in Postmenopausal Women: Differences between Early and Late Post-Menopause,” European Journal of Obstetrics & Gynecology and Reproductive Biology, Vol. 145, No. 1, 2009, pp. 81-84.
[20] D. R. S. De Lorenzi, E. C. Baracat, B. Saciloto and J. R. I. Padilha, “Fatores Associados à Qualidade de vida após Menopausa,” Revista da Associação Médica Brasileira, Vol. 52, No. 5, 2006, in press.
[21] E. R. Alpizar and D. N. Despaigne, “Factores Relacionados con la Demanda de Atención Médica para el Climaterio,” Revista Cubana de Endocrinología, Vol. 14, No. 3, 2003, in press.
[22] R. L. Sousa, R. G. Filizola, M. F. F. Diniz, E. S. S. Sousa and J. L. R. Moraes, “Ensaio Clínico Placebo-Controlado com Isoflavonas da Soja,” Revista Brasileira de Ginecologia e Obstetrícia, Vol. 28, No. 2, 2006, pp. 91-100.
[23] J. B. Howes, K. Bray, L. Lorenz, P. Smerdely and L. G. Howes, “The Effects of Dietary Supplementation with Isoflavones from Red Clover on Cognitive Function in Postmenopausal Women,” Climacteric, Vol. 7, No. 1, 2004, pp. 70-77.
[24] S. Kreijkamp-Kaspers, L. Kok, D. E. Grobbee, E. H. Haan, A. Aleman, J. W. Lampe and Y. T. Van der Schouw, “Effect of Soy Protein Containing Isoflavones on Cognitive Function, Bone Mineral Density, and Plasma Lipids in Postmenopausal Women: A Randomized Controlled Trial,” JAMA, Vol. 292, No. 1, 2004, pp. 65-74.
[25] S. C. Ho, A. S. Chan, Y. P. Ho, E. K. So, A. Sham, B. Zee and J. L. Woo, “Effects of Soy Isoflavone Supplementation on Cognitive Function in Chinese Postmenopausal Women: A Double-Blind, Randomized, Controlled Trial,” Menopause, Vol. 14, No. 3, 2007, pp. 489-499.
[26] M. S. Beeri, J. Schmeidler, M. Sano, J. Wang, R. Lally and H. Grossman, “Age, Gender, and Education Norms on the CERAD Neuropsychological Baterry in the Oldest Old,” Neurology, Vol. 67, No. 6, 2006, pp. 1006-1010.

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