Efferocytosis in Retinoblastoma

Dipankar Das, Harsha Bhattacharjee, Kasturi Bhattacharjee, Prerana S. Tahiliani, Pankaj Bhattacharyya, Manabjyoti Barman, Sumita Sarma Barthakur, Panna Deka, Apurba Deka, Rajashree Paul

Sri Sankaradeva Nethralaya, Guwahati, India.

DOI: 10.4236/jct.2013.49172                

Abstract

Retinoblastoma has varied presentations. As age advances in retinoblastoma, the undifferentiated tumour is the common appearance. Apoptosis in retinoblastoma in an untreated case can give us a clue about the tumour biology. Efferocytosis in intraocular tumour is a new concept which was seen in an enucleated eyeball specimen in a 4-year-old boy. Effective efferocytosis can be conceptualized for new pharmacodynamics application for anti-cancer drugs. We present a rare case of retinoblastoma with efferocytosis in retinal pigment epithelium and interesting apoptotic changes.

Keywords

Retinoblastoma; Apoptosis; Efferocytosis; Vesicles; Undifferentiated

Conflicts of Interest

The authors declare no conflicts of interest.

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