Primary Cervical Choriocarcinoma: Case Report and the Review of Literatures

N. Behtash, M. Karimi Zarchi, A. A. Shamshirsaz, A. A. Shamshirsaz, Ashrafosadt Miratashi-Yazd, N. Mehrdad

Gynecological Oncology Fellowship, Shahid Sadoughi University of Medical Science, Yazd, Iran.

DOI: 10.4236/jct.2013.48158                

Abstract

Background: Primary choriocarcinoma of the cervix is a very rare entity. Case: A 35-year-old patient had been admitted to our hospital with vaginal bleeding for 7 months. A cervical mass measured 4 × 4 cm was palpated on the anterior surface of the cervix. Biopsy of the lesion demonstrated extensive necrosis and was in favor of squamous cell carcinoma. Patient was accepted as FIGO stage I_b1-2 and underwent type II hysterectomy with bilateral salpingoopherectomy and bilateral pelvic lymph node dissection was carried out. Post operative pathologic evaluation of the surgical specimen evinced that the case was primary cervical choriocarcinoma. Conclusion: Primary choriocarcinoma of the cervix should be considered in patients in their reproductive years with cervical lesion and negative cervical cytology. Beta-hCG assay and transvaginal color Doppler sonography are useful for early diagnosis.

Keywords

Choriocarcinoma; Cervix; Primary

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	M. Saito, T. Azuma and K. Nakamura, “On Ectopic Choriocarcinoma,” World Journal of Obstetrics and Gynecology, Vol. 17, 1965, pp. 459-484.
[2]	C. Baykal, G. Tulunay, D. Bulbul, N. Boran and M. F. Kose, “Primary Choriocarcinoma of the Uterine Cervix in a Postmenopausal Patient: A Case Report,” Gynecologic Oncology, Vol. 90, No. 3, 2003, pp. 667-669. http://dx.doi.org/10.1016/S0090-8258(03)00369-X
[3]	Y. Fu, W. Lu, C. Zhou and X. Xie, “Primary Cervical Choriocarcinoma: Report of Four Cases and Literature Review,” International Journal of Gynecological Cancer, Vol. 17, No. 3, 2007, pp. 715-719. http://dx.doi.org/10.1111/j.1525-1438.2007.00819.x
[4]	T. Yahata, S. Kodama, H. Kase, N. Sekizuka, T. Kurabayashi, Y. Aoki and K. Tanaka, “Primary Choriocarcinoma of the Uterine Cervix: Clinical, MRI, and Color Doppler Ultrasonographic Study,” Gynecologic Oncology, Vol. 64, No. 2, 1997, pp. 274-278. http://dx.doi.org/10.1006/gyno.1996.4541
[5]	R. Roopnarinesingh, S. Igoe and J. E. Gillan, “Choriocarcinoma-Presenting as a Primary Lesion of the Cervix,” Irish Medical Journal, Vol. 97, 2004, pp. 147-148.
[6]	S. S. Al Hassani and G. C. Ejeckam, “Primary Cervical Choriocarcinoma,” Tropical and Geographical Medicine, Vol. 47, 1995, pp. 308-309.
[7]	B. R. Herts, J. M. Yee and R. F. Porges, “Primary Cervical Choriocarcinoma: Case Report and Review of Literature,” Journal of Ultrasound in Medicine, Vol. 12, 1993, pp. 59-62.
[8]	N. P. Veridiano, D. Gal, I. Delke, Y. Rosen and M. L. Tancer, “Gestational Choriocarcinoma of the Ovary,” Gynecologic Oncology, Vol. 10, No. 2, 1980, pp. 235-240. http://dx.doi.org/10.1016/0090-8258(80)90087-6
[9]	M. G. Muto, J. M. Lage, R. S. Berkowitz, D. P. Goldstein and M. R. Bernstein, “Gestational Choriocarcinoma Disease of the Fallopian Tube,” Journal of Reproductive Medicine, Vol. 36, 1991, pp. 57-60.
[10]	S. Weiss, A. Amit, M. R. Schwartz and A. L. Kaplan, “Primary Choriocarcinoma of the Vulva,” International Journal of Gynecological Cancer, Vol. 11, No. 3, 2001, pp. 251-254. http://dx.doi.org/10.1046/j.1525-1438.2001.01005.x
[11]	H. Sonobe, K. Taguchi, K. Ogawa and T. Yoshioka, “Latent Vaginal Choriocarcinoma in a Postmenopausal Woman,” Acta Pathologica Japonica, Vol. 26, 1976, pp. 611-618.
[12]	FIGO Oncology Committee Report, “FIGO Staging for Gestational Trophoblastic Neoplasia 2000,” International Journal of Gynecology & Obstetrics, Vol. 77, No. 3, 2002, pp. 285-287. http://dx.doi.org/10.1016/S0020-7292(02)00063-2
[13]	P. Y. Wel snd P. C. Ouyang, “Trophoblastic Disease in Taiwan: A Review of 157 Cases on a 10-Year Period,” American Journal of Obstetrics & Gynecology, Vol. 85, 1963, pp. 844-849.
[14]	P. C. Dyke and L. M. Fink, “Latent Choriocarcinoma,” Cancer, Vol. 20, No. 1, 1967, pp. 150-154. http://dx.doi.org/10.1002/1097-0142(1967)20:1<150::AID-CNCR2820200121>3.0.CO;2-9
[15]	W. Park, “Choriocarcinoma: A Study of Its Pathology,” F. A. Davis, Philadelphia, 1971.
[16]	N. Tsukamoto, M. Nakamura, M. Kashimura and T. Saito, “Primary Cervical Choriocarcinoma,” Gynecologic Oncology, Vol. 9, No. 1, 1980, pp. 99-107. http://dx.doi.org/10.1016/0090-8258(80)90014-1
[17]	E. Kairi-Vassilatou, K. Papakonstantinou, D. Grapsa, A. Kondi-Paphiti and D. Hasiakos “Primary Gestational Choriocarcinoma of the Uterine Cervix,” International Journal of Gynecological Cancer, Vol. 17, No. 4, 2007, pp. 921-925. http://dx.doi.org/10.1111/j.1525-1438.2006.00852.x
[18]	A. Ben-Chetrit, S. Yagel, I. Ariel, D. Zacut, S. Shimonovitz and D. Ceinikier-Hochner, “Successful Conservative Management of Primary Nonmetastatic Cervical Choriocarcinoma,” American Journal of Obstetrics & Gynecology, Vol. 163, No. 4, 1990, pp. 1161-1163. http://dx.doi.org/10.1016/0002-9378(90)90679-2