Pectin-Based Biodegradable Hydrogels with Potential Biomedical Applications as Drug Delivery Systems
Mohammad Sadeghi
DOI: 10.4236/jbnb.2011.21005   PDF    HTML     10,131 Downloads   16,502 Views   Citations


In this work, synthesis and swelling behavior of a superabsorbent hydrogel based on Pectin (Pc) and polyacrylonitrile (PAN) were investigated. A mechanism for hydrogel formation was proposed and the structure of the product was es-tablished using FTIR spectroscopy. The Pc-poly (sodium acrylate-co-acrylamide) hydrogel exhibited a pH-responsive swelling-deswelling behavior at pH’s 2 and 8. This on-off switching behavior provides the hydrogel with the potential to control delivery of bioactive agents. Release profiles of ibuprofen (IBU), a poor water-soluble drug, from the hydro-gels were studied under both simulated gastric and intestinal pH conditions.

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Sadeghi, M. (2011) Pectin-Based Biodegradable Hydrogels with Potential Biomedical Applications as Drug Delivery Systems. Journal of Biomaterials and Nanobiotechnology, 2, 36-40. doi: 10.4236/jbnb.2011.21005.

Conflicts of Interest

The authors declare no conflicts of interest.


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