Synthesis and bioevaluation of novel heterostilbenes as potential anti-inflammatory and anti-angiogenic agents


Novel heterocyclic analogs of resveratrol, (E)-stilbene analogs, were readily prepared by conjugation of a heterocyclic benzothiazolium moiety with the core styrene structure of resveratrol and evaluated for their biological properties. The results showed that these analogs were superior to resveratrol in 1) anti-angiogenesis in vitro, 2) nitric oxide inhibition in vitro, and 3) inhibition of carrageenan-induced edema in vivo. In summary, introduction of a heterocyclic benzothiazolium moiety to replace one of two aromatic rings from the core stilbene structure of resveratrol provided beneficial biological properties and is worthy of further investigation.

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Huang, C. , Lee, A. , Shaw, J. and Huang, W. (2013) Synthesis and bioevaluation of novel heterostilbenes as potential anti-inflammatory and anti-angiogenic agents. Modern Research in Inflammation, 2, 37-45. doi: 10.4236/mri.2013.23005.

Conflicts of Interest

The authors declare no conflicts of interest.


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