Efficacy and Safety of Nasal Administration of “Na-no-L-DOPA” Based on PLGA Nanoparticles


Inclusion of L-DOPA, the standard Parkinson’s disease medication, into polymeric particles (PLGA) results in optimization the drug metabolism and increasing its bioavailability, significantly increases of physical endurance, better coordination and lower anxiety in Wistar rats, when chronically administered nasally.

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I. Kondrasheva, T. Antipova, G. Barsegyan, P. Gambaryan, A. Guseva and A. Kamensky, "Efficacy and Safety of Nasal Administration of “Na-no-L-DOPA” Based on PLGA Nanoparticles," Engineering, Vol. 4 No. 10B, 2012, pp. 27-29. doi: 10.4236/eng.2012.410B007.

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The authors declare no conflicts of interest.


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