Diuretic activity of Phyllanthus niruri (Linn.) in rats


Aqueous extract of Phyllanthus niruri (200 mg/kg and 400 mg/kg. p.o. single dose) was tested for its diuretic activity and compared with the standard drug hydrochlorothiazide (10 mg/ kg p.o.; single dose). Significant increase in the volume of urine and excretion of sodium, potassium and chloride was recorded when aqueous extract of Phyllanthus niruri was administered to hydrated albino rats.

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Udupa, A. , ., S. , Benegal, A. , Prusty, V. , Kodancha, G. , Kumar, M. , Bhat, V. and Ratnakar, U. (2010) Diuretic activity of Phyllanthus niruri (Linn.) in rats. Health, 2, 511-512. doi: 10.4236/health.2010.25076.

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The authors declare no conflicts of interest.


[1] Nadkarni, A.K. (2002) Indian Materia Medica. Popular Prakashan Private Limited, 1, 947.
[2] Crosland, J. (1980) Lewis Pharmacology Churchill Livingstone Inc. New York, 137-146.
[3] Hwang, K. and Goldberg, M.E. (1959) Federation proceedings, 18, 405.
[4] Schaumann, O. (1960), Archaic experimental Pathology Pharmaceutical, 238, 219.

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