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Frequent Episodic Vertigo is an Unexpected Side Effect of Flutamide

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DOI: 10.4236/pp.2011.24043    3,377 Downloads   6,685 Views  

ABSTRACT

An 82-year-old male suffered from prostatic cancer five years ago. Since then, he has taken flutamide and was bothered with episodic vertigo (EV) every morning. In order to treat prostatic cancer, flutamide was not discontinued, but conservative treatment and life-style change were recommended. Finally, EV actually subsided. Herein, we report the rare case, in which EV was an unexpected side effect of flutamide. Herein we review his whole history, physical examination, vestibular function test, electronystagmogram, caloric test, awake encephalogram, blood examinations, color-coded duplex ultrasonogram and magnetic resonance imaging/angiogram to suggest a mechanism of flutamide responsible for EV.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

J. Chen and D. Chen, "Frequent Episodic Vertigo is an Unexpected Side Effect of Flutamide," Pharmacology & Pharmacy, Vol. 2 No. 4, 2011, pp. 338-340. doi: 10.4236/pp.2011.24043.

References

[1] D.G. McLeod, “Antiandrogenic drugs,” Cancer; Vol. 71, No. 3 Suppl, 1993, pp. 1046-1049.
[2] E.J. Dole and M.T. Holdsworth, “Flutamide: an antiandrogen for the treatment of prostate cancer,” Ann Pharmacotherapy, Vol. 31, No. 1, 1997, pp. 65-75.
[3] H. Lepor, “Alpha blockers for the treatment of benign prostatic hyperplasia,” Rev Urol, Vol. 9, No. 4, 2007, pp. 181-190.
[4] R. Kirby and A. Jardin, “Doxazosin in the treatment of benign prostatic hyperplasia. A review of the safety profile in older patients,” Prostate Cancer Prostatic Dis, Vol. 1, No. 2, 1997, pp. 84-89.
[5] H.W. Chen, P.S. Yen, C.C. Lee, C.C. Chen, P.Y. Chang, S.K. Lee, W.H. Lee, C.M. Ling and A.S.B. Chou, “Magnetic resonance angiographic evaluation of circle of Willis in general population: a morphologic study in 507 cases,” Chin J Radiol, Vol. 29, No. 5, 2004, pp. 223-229.
[6] D.F. Schomer, M.P. Marks, G.K. Steinberg, I.M. Johnstone, D.B. Boothroyd, M.R. Ross, N.J. Pelc and D.R. Enzmann, “The anatomy of the posterior communicating artery as a risk factor for ischemic cerebral infarction,” N Engl J Med, Vol. 330, No. 22, 1994, pp. 1565-1570.
[7] J.M. Hong, C.S. Chung, O.Y. Bang, I.S. Joo and K. Huh, “Vertebral artery dominance contributes to basilar artery curvature and peri-vertebrobasilar junctional infarcts,” J Neurol Neurosurg Psychiatry, Vol. 80, No. 10, 2009, pp. 1087-1092.
[8] G.R. Ward and A.A. Abdel-Rahman, “Orchiectomy or androgen receptor blockade attenuates baroreflex-mediated bradycardia in conscious rats,” BMC Pharmacol, Vol. 6, 2006, pp. 2.
[9] B. Xue, A.K. Johnson and M. Hay, “Sex differences in angiotensin II- induced hypertension,” Braz J Med Biol Res, Vol. 40, No. 5, 2007, pp. 727-734.

  
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