The Influence of Different Sterilization Techniques on the Time-Dependent Behavior of Polyamides
G. Kubyshkina, B. Zupančič, M. Štukelj, D. Grošelj, L. Marion, I. Emri
DOI: 10.4236/jbnb.2011.24045   PDF    HTML     9,705 Downloads   16,831 Views   Citations


For this investigation conventional polyamide 6 with monomodal molecular mass distribution, and the newly developed bimodal one were used. Conventional polyamide 6 was used as a reference material in order to emphasize prospects of using bimodal material for medical applications from the point of view of sterilization resistance and improved creep behavior. Time-dependent mechanical properties of testing samples were characterized by torsional creep measurements in non-sterilized state and after sterilization with three different techniques: with autoclave, ethylene oxide, and hydrogen peroxide plasma. Results show that the two materials exhibit pronounced difference in morphology and consequently, mechanical properties. Both of them were not significantly affected by any of used sterilization techniques. However, bimodal material, originally being noticeably more time-stable in comparison to monomodal one, retains these preferences also post sterilization.

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G. Kubyshkina, B. Zupančič, M. Štukelj, D. Grošelj, L. Marion and I. Emri, "The Influence of Different Sterilization Techniques on the Time-Dependent Behavior of Polyamides," Journal of Biomaterials and Nanobiotechnology, Vol. 2 No. 4, 2011, pp. 361-368. doi: 10.4236/jbnb.2011.24045.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] L. K. Massey, “The Effects of Sterilization Methods on Plastics and Elastomers, 2nd ed., The Definitive User’s Guide and Databook,” Wlliam Andrew publishing, 2004.
[2] J. R. Davis, “Handbook of materials for medical devices,” ASM International, 2004.
[3] C. Fischbach, J. Tessmar, A. Lucke, E. Schnell, G. Schmeer, T. Blunk, A. Gopferich, ”Does UV irradiation affect polymer properties relevant to tissue engineering?,” Surface Science, Vol. 491, No. 3, 2001, pp. 333-345.
[4] D. Slatter, “Textbook of small animal surgery. 3rd ed.,” Elsevier Science, 2003.
[5] Y. H. An, F. I. Alvi, Q. Kang, M. Laberge, M. J. Drews, J. Zhang, M. A. Matthews, C. R. Arciola, “Effects of sterilization on implant mechanical property and biocompatibility,” The International Journal of Artificial Organs, 28, 2005, pp. 1126-1137.
[6] W. Rogers, “Sterilisation of Polymer Healthcare Products,” Rapra Technology limited, 2005.
[7] P. D. Nair, P. J. Doherty, D. F. Williams, “Influence of steam sterilization induced surface changes of polyester materials on its biocompatibility,” Bulletin of Material Science, Vol. 20, No. 7, 1997, pp. 991-9.
[8] J. H. Young, “Steam sterilization: Scientific principles,” In: M. Reichert, J. H. Young, eds., “Sterilization technology for the health care facility,” Gaithersburg, MD: Aspen Publishers, 1997, pp. 124-33.
[9] I. P. Matthews, C. Gibson, A. H. Samuel, ”Sterilisation of implantable devices,” Clinical Materials, 15, 1994, pp. 191-215.
[10] R. C. Portnoy, “Medical Plastics - Degradation Resistance & Failure Analysis. Plastics Design Library”, A Division of William Andrew Inc., Norwich, New York, 1998.
[11] Y. Marois, Z. Zhang, M. Vert, X. Deng, R. Lenz, R. Guidoin, “Effect of sterilization on the physical and structural characteristics of polyhydroxyoctanoate (PHO)”, Journal of Biomaterials Science, Polymer Edition, 1999, pp. 469-482.
[12] A. D. Lucas, K. Merritt, V. M. Hitchins, T. O. Woods, S. G. McNamee, D. B. Lyle, S. A. Brown, “Residual Ethylene Oxide in Medical Devices and Device Material,” Journal of Biomedical Materials Research, Part B, 66(2), 2003, pp. 548-52.
[13] I. Buben, V. Melichercikova, N. Novotna, R. Svitakova, “Problems Associated with Sterilization using Ethylene Oxide. Residues in Treated Materials,” Central European Journal of Public Health, Vol. 7, No. 4, 1999, pp. 197- 202.
[14] S. A. Brown, K. Merritt, T. O. Woods, S. G. McNamee, V. M. Hitchins, “Effects of Different Disinfection and sterilization methods on tensile strength of materials used for singleuse devices,” Biomedical Instrumentation and Technology, 36, 2002, pp. 23-27.
[15] S. Lerouge, M. Tabrizian, M. R. Wertheimer, R. Marchand, L’H Yahia, “Safety of plasma -based sterilization: Surface modifications of polymeric medical devices induced by Sterrad? and PlazlyteTM processes,” Bio- Medical Materials and Engineering, 12, 2002, pp. 3-13.
[16] N. Ma, A. Petit, O. L. Huk, L. Yahia, M. Tabrizian, “Safety issue of resterilization of polyurethane electrophysiology catheters: a cytotoxicity study,” Journal of Biomaterials Science, Polymer Edition, Vol. 14, No. 3, 2003, pp. 213-226.
[17] (last access on the 15th of July, 2011).
[18] G. K. Sicard, K. Hayashi, P. A. Manley, “Evaluation of 5 Types of Fishing Material, 2 Sterilization Methods, and a Crimp-Clamp System for Extra-Articular Stabilization of the Canine Stifle Joint,” Veterinary Surgery, Vol. 31, No. 1, 2002, pp. 78-84.
[19] B. M. Kirby, J. W. Wilson, “Knot strength of nylonband cerclage,” Acta Orthopaedica Scandinavica, Vol. 60, No. 6, 1989, pp. 696-8.
[20] G. B. Bochkova, A. S. Yushin, “Impact of Some Liquids and Steam Sterilization on the Strength of Polyamide Membranes, ” Khimiko-Farmatsevticheskii Zhurnal, Vol. 25, No. 5, 1991, pp. 78-81.
[21] M. Gatineau, L. Huneault, B. Lussier, J. Lefevre-Lavoie, “Mechanical Evaluation of Hydrogen Peroxide Gas Plasma Sterilization of Nylon Lines Used for Extra-Articular Stabilization of the Canine Stifle Joint,” Veterinary Surgery, Vol. 39, No. 1, 2010, pp. 48-53.
[22] I. Emri, B. S. von Bernstorff, “The Effect of Molecular Mass Distribution on Time-Dependent Behavior of Polyamides,” Journal of Applied Mechanics, 73, 2006, pp. 1-6.
[23] N. W. Tschoegl, “The phenomenological theory of linear viscoelastic behavior: An introduction,” Springer-Verlag, Berlin, Heidelberg, 1989.
[24] J. J. Aklonis., W. J. Macknight, M. Shen, “Introduction to polymer viscoelasticity, 2nd ed.,” 1983.
[25] P. Metlikovi?, I. Emri, “Analiza procesa lezenja viskoelasti?nih materialov pod vplivom stri?ne obremenitve,” Kovine, zlitine, tehnologije, Vol. 28, No. 1-2, 1994, pp. 407-409.
[26] R. Cvelbar, I. Emri, “Analiza prehodnega pojava pri merjenju lezenja viskoelasti?nih materialov,” Kovine, zlitine, tehnologije, Vol. 28, No. 1-2, 1994, pp. 359-362.
[27] M. Gergesova, B. Zupan?i?, I. Saprunov, I. Emri, “The closed form t-T-P shifting (CFS) algorithm,” Journal of Rheology, (N.Y. N.Y.), Vol. 55, No. 1, 2011, pp. 1-16.
[28] M. Ayson, J. Leichter, K. Lyons, “Dental Implants: Patient Selection Factors. Evidence-Based Review,” 2009.
[29] V. Pavsek, I. Emri, “On the influence of moisture on the mechanical-properties of polymers,” Journal of Mechanical Engineering, Vol. 41, No. 1-2, 1995, pp. 39-45.

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