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Synthesis and Biological Evaluation of Novel Homopiperazine Derivatives as Anticancer Agents

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DOI: 10.4236/jct.2011.24069    5,110 Downloads   9,560 Views   Citations

ABSTRACT

In search of new anticancer agents, a series of novel 1-benzhydryl-4-(substituted phenylcarboxamide / carbothioamide)-1,4-diazepane derivatives were designed, synthesized and characterized using 1H NMR, LCMS and elemental analysis. These molecules were evaluated for their anti-cancer activity by trypan blue exclusion and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay on B-cell leukemic cell line, Reh. Carboxamide moiety containing derivatives showed good activity compared to the corresponding carbothioamide derivatives. In particular, 4-benzhydryl-N-(3-chlorophenyl)-1,4-diazepane-1-carboxamide showed good activity with IC50 value of 18 µM.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

S. Teimoori, K. Panjamurthy, K. Vinaya, D. Prasanna, S. Raghavan and K. Rangappa, "Synthesis and Biological Evaluation of Novel Homopiperazine Derivatives as Anticancer Agents," Journal of Cancer Therapy, Vol. 2 No. 4, 2011, pp. 507-514. doi: 10.4236/jct.2011.24069.

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