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Vasoactive Intestinal Peptide (VIP) and VIP Receptors-Elucidation of Structure and Function for Therapeutic Applications

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DOI: 10.4236/ijcm.2011.24084    6,431 Downloads   10,315 Views   Citations

ABSTRACT

Vasoactive intestinal peptide (VIP) is a 28-amino acid polypeptide first isolated from swine duodenum. VIP is a neurotransmitter that is extensively distributed in tissues. According to published reports, VPAC1 and VPAC2 act as VIP receptors and are widely present in the central nervous system and peripheral tissues. VIP exerts diverse actions on the cardiovascular system, pancreas, digestive tract, respiratory system, and urological system. Recent reports indicated that VIP has immunological and neuroprotective effects and also affects cell growth. While primary investigations for developing therapeutic applications for various pathological conditions and diseases are underway, the structure and function of VIP should be analyzed in more detail.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

H. Igarashi, N. Fujimori, T. Ito, T. Nakamura, T. Oono, K. Nakamura, K. Suzuki, R. Jensen and R. Takayanagi, "Vasoactive Intestinal Peptide (VIP) and VIP Receptors-Elucidation of Structure and Function for Therapeutic Applications," International Journal of Clinical Medicine, Vol. 2 No. 4, 2011, pp. 500-508. doi: 10.4236/ijcm.2011.24084.

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