Share This Article:

Prevalence of Malaria Infection among People Living with HIV in Kinshasa

DOI: 10.4236/oalib.1101077    268 Downloads   500 Views   Citations

ABSTRACT

Background: Infection with the Human Immunodeficiency Virus (HIV) and malaria are two infectious diseases which are among the leading causes of morbidity and mortality in Sub-Saharan Africa and each a major public health problem. Data on malaria infection among people living with HIV (PLHIV) are poorly defined in Kinshasa as there are very few studies available on the subject. Objective: To determine the rate of co-infection HIV/malaria in Kinshasa to improve the care of PLHIV, this study was initiated to update the data. Methodology: This study was a prospective cohort. 123 volunteers participated in this study in the third month. 114 patients completed the 6- month visit. Malaria diagnosis by microscopy was performed at the two medical visits. A sample of 5 ml of blood was also drawn in a tube with EDTA for the determination of viral load and measuring the level of CD4 T cells. Results: In the third month of Antiretroviral Therapy (ART), we had 123 PLHIV (78 women and 45 men). Viral loads (VL) ranged from 390.79 copies/ml (2.59 log10) and 38546691.53 copies/ml (6.59 log10). The CD4 ranged between 90 and 547 cells/mm3. 25 patients (20.33%) were positive for malaria. At 6th month of ART, there were 114 patients (75 women and 39 men). The CV of the population ranged from 0 copies/ml and 2693671.54 copies/ml (6.43 log10). The CD4 at 6th month were in the range between 421 and 984 cells/mm3. 20 patients (17.54%) presented positive thick smear for malaria. Conclusion: The prevalence rate of HIV/ malaria co-infection varies between 17.54% and 20.33% in Kinshasa.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Kamangu, E. , Muhindo, H. , Wapa-Kamangu, C. and Situakibanza, H. (2015) Prevalence of Malaria Infection among People Living with HIV in Kinshasa. Open Access Library Journal, 2, 1-6. doi: 10.4236/oalib.1101077.

References

[1] UNAIDS (2012) Global Summary on the AIDS Epidemic.
[2] World Health Organization (WHO) (2013) World Malaria Report 2013. World Health Organization, Geneva.
[3] Organisation Mondiale de la Santé (OMS) (2004) Paludisme et VIH: Interactions et répercussions sur les politiques de santé publique. Rapport d’une consultation technique, Genève.
[4] UNAIDS/WHO. AIDS Epidemic Update December 2012.
[5] Skinner-Adams, T.S., McCarthy, J.S., Gardiner, D.L. and Andrews, K.T. (2008) HIV and Malaria Co-Infection: Interactions and Consequences of Chemotherapy. Trends in Parasitology, 24, 264-271.
http://dx.doi.org/10.1016/j.pt.2008.03.008
[6] Rénia, L. and Potter, S.M. (2006) Co-Infection of Malaria with HIV: An Immunological Perspective. Parasite Immunology, 28, 589-595.
[7] Van Geertruyden, J.P. and D’Alessandro, U. (2007) Malaria and HIV—A Silent Alliance. Trends in Parasitology, 23, 465-467.
http://dx.doi.org/10.1016/j.pt.2007.08.006
[8] Abu-Raddad, L.J., Patnaik, P. and Kublin, J.G. (2006) Dual Infection with HIV and Malaria Fuels the Spread of Both Diseases in Sub-Saharan Africa. Science, 314, 1603-1606.
http://dx.doi.org/10.1126/science.1132338
[9] Aoussi, E.F., Tanon, K.A., Ehui, E., Ouattara, S.I., Inwoley, K.A., Adou-Bryn, K.D., Eholié, S.P. and Bissagnéné, E. (2011) Paludisme et infection à VIH en Afrique subsaharienne: Encore un couple maudit ? Sante, 21, 174-177.
[10] Programme National de la Lutte contre le Sida et les IST (PNLS), Ministère de la Santé Publique, République Démocratique du Congo. Rapport 2009. Avril 2010.
[11] Ministère de la Santé Publique, République Démocratique du Congo. Bulletin épidémiologique 2010, Mars 2011.
[12] Kamangu, N.E., Chatté, A., Boreux, R., Kalala, L.R., Mvumbi, L.G., Vaira, D. and Hayette, M.P. (2014) Mise en place d’une PCR Quantitative Temps Réel pour l’évaluation de la Charge Virale pour VIH à Kinshasa. Journal de Recheche BioMédicale, 1, 7-12.
[13] Kamangu, N.E., Chatte, A., Boreux, R., Kalala, L.R., Mvumbi, L.G., De Mol, P., Vaira, D. and Hayette, M.P. (2014) Implementation of an In-House Quantitative Real-Time PCR for Determination of HIV Viral Load in Kinshasa. Open Access Library Journal, 1, e855.
[14] Modia, A.O., Foidart, J.M. and Rigo, J. (2011) Influence de la coinfection paludéenne placentaire et VIH sur la biométrie et l’indice d’Apgar du nouveau-né à Kinshasa, République Démocratique du Congo. Journal de Gynécologie Obstétrique et Biologie de la Reproduction, 40, 460-464.
http://dx.doi.org/10.1016/j.jgyn.2011.03.002
[15] Saracino, A., Nacarapa, E.A., da Costa Massinga, E.A., Martinelli, D., Scacchetti, M., de Oliveira, C., Antonich, A., Galloni, D., Ferro, J.J. and Macome, C.A. (2012) Prevalence and Clinical Features of HIV and Malaria Co-Infection in Hospitalized Adults in Beira, Mozambique. Malaria Journal, 11, 241.
http://dx.doi.org/10.1186/1475-2875-11-241
[16] Nyimi, M.L., Lepira, B.F., Sumaili, K.E., Ebengo, B.C., Nseka, M.N. and Longo-Mbenza, B. (2001) Insuffisance rénale aïgue associée à l’infection par le VIH à Kinshasa: à propos de 24 observations. Louvain Médical, 120, 167- 172.
[17] Kamangu, N.E., Situakibanza, N.H., Mvumbi, L.G., Kakudji, I.L., Tshienda, T.D. and Mesia, K.G. (2012) Infections opportunistes chez les personnes vivant avec le VIH suivies à l’Hôpital Militaire de Référence de Kinshasa (Camp Kokolo). Revue Congolaise des Sciences, 1, 66-76.
[18] Situakibanza, N.H., Kapita, M.B., Mbendi, N., Odio, W., Mbula, M., Muvova, D., Mizerero, D. and Izzia, K. (1996) Etiologie de la fièvre au cours du SIDA: à propos de 64 cas. Panorama Medicale, 1, 842-845.
[19] Kamangu, N.E., Kawila, M.E., Mukumbi, H. and Mvumbi, L.G. (2012) Estimated Rates of Treatment Failure in First-Line Antiretroviral Treatment in Kinshasa: Case of the ACS AMO-Congo. International Journal of Collaborative Research on Internal Medicine and Public Health, 4, 885-891.

  
comments powered by Disqus

Copyright © 2019 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.