Perceived happiness level influences evocation of positive emotions


Happiness is a positive feeling characterized by satisfaction, joy, pleasure, or love. Perceived happiness level is likely associated with health and well-being. However, the neurobiological mechanisms underlying the positive effects of happiness on psychological and physiological wellness remain obscure. In this study, we found that the medial prefrontal cortex (MPFC) was strongly activated and positive emotions were strongly evoked in individuals with high perceived happiness levels compared to those with low perceived happiness levels when either looked at a favorite person. Moreover, positive mood changes were positively correlated with MPFC activity. These results show that perceived happiness level is associated with positive emotion evocation by means of the MPFC function, which may be involved in psychological and physiological wellness. Therefore, happiness may play an important role in psychological and physiological wellness.

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Matsunaga, M. , Murakami, H. , Yamakawa, K. , Isowa, T. , Fukuyama, S. , Shinoda, J. , Yamada, J. and Ohira, H. (2011) Perceived happiness level influences evocation of positive emotions. Natural Science, 3, 723-727. doi: 10.4236/ns.2011.38095.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Magalhaes, A.C., Holmes, K.D. and Dale, L.B., Comps- Agrar, L., Lee, D. and Yadav, P.N. et al. (2010) CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling, Nat Neuroscience, 13, 622-629. doi:10.1038/nn.2529
[2] Maisel, A.S., Knowlton, K.U., Fowler, P., Rearden, A., Ziegler, M.G. and Motulsky, H.J. et al. (1990) Adrenergic control of circulating lymphocyte subpopulations. Effects of congestive heart failure, dynamic exercise and terbutaline treatment, The Journal of Clinical Investigation, 85, 462-467. doi:10.1172/JCI114460
[3] Jacobs, J.R. and Bovasso, G.B. (2000) Early and chronic stress and their relation to breast cancer, Psychological Medicine, 30, 669-678. doi:10.1017/S0033291799002020
[4] Horiuchi, S., Tsuda, A., Hashimoto, E., Kai, H. and Wenjie, H. (2008) Effect of perceived happiness level on cardiac response to mental stress testing: a pilot study, Japan Journal Biofeedback Research, 35, 93-98.
[5] Shimai, S., Otake, K., Utsuki, N., Ikemi, A. and Lyubom- irsky, S. (2004) Development of a Japanese version of the subjective happiness scale (SHS) and examination of its validity and reliability, Japan Journal Public Health, 51, 845-853.
[6] Juckel, G., Mendlin, A. and Jacobs, B.L. (1999) Electrical stimulation of rat medial prefrontal cortex enhances forebrain serotonin output: implications for electroconvulsive therapy and transcranial magnetic stimulation in depression, Neuropsychopharmacology, 21, 391-398. doi:10.1016/S0893-133X(98)00097-9
[7] Matsunaga, M., Isowa, T., Kimura, K., Miyakoshi, M., Kanayama, N. and Murakami, H. et al. (2008) Associations among central nervous, endocrine, and immune activities when positive emotions are elicited by looking at a favorite person, Brain Behavior and Immunity, 22, 408-417. doi:10.1016/j.bbi.2007.09.008
[8] Friston, K.J., Holmes, A.P., Worsley, K.J., Poline, J.-P., Frith, C.D. and Frackowiak, R.S.J. (1995) Statistical parametric maps in functional imaging: a general linear approach, Human Brain Mapping, 2, 189-210. doi:10.1002/hbm.460020402
[9] Ohira, H., Isowa, T., Nomura, M., Ichikawa, N., Kimura, K. and Miyakoshi, M. et al. (2008) Imaging brain and immune association accompanying cognitive appraisal of an acute stressor, Neuroimage, 39, 500-514. doi:10.1016/j.neuroimage.2007.08.017
[10] Aron, A., Fisher, H., Mashek, D.J., Strong, G., Li, H. and Brown, L.L. (2005) Reward, motivation, and emotion systems associated with early-stage intense romantic love, Journal of Neurophysiology, 94, 327-337. doi:10.1152/jn.00838.2004
[11] Bartels, A. and Zeki, S. (2004) The neural correlates of maternal and romantic love, NeuroImage, 21, 1155-1166. doi:10.1016/j.neuroimage.2003.11.003
[12] Verhoeff, N.P., Christensen, B.K., Hussey, D., Lee, M., Papatheodorou, G. and Kopala, L. et al. (2003) Effects of catecholamine depletion on D2 receptor binding, mood, and attentiveness in humans: a replication study, Pharmacology Biochemistry Behavior, 74, 425-432. doi:10.1016/S0091-3057(02)01028-6
[13] Yadid, G. and Friedman, A. (2008) Dynamics of the dopaminergic system as a key component to the understanding of depression, Progress in Brain Research, 172, 265-286. doi:10.1016/S0079-6123(08)00913-8
[14] Roth-Deri, I., Friedman, A., Abraham, L., Lax, E., Flaumenhaft, Y. and Dikshtein, Y. et al. (2009) Antidepressant treatment facilitates dopamine release and drug seeking behavior in a genetic animal model of depression, Europe Journal of Neuroscience, 30, 485-492. doi:10.1111/j.1460-9568.2009.06840.x
[15] Critchley, H.D., Mathias, C.J., Josephs, O., O’Doherty, J., Zanini, S. and Dewar, B.K. et al. (2003) Human cingulate cortex and autonomic control: converging neuroimaging and clinical evidence, Brain, 126, 2139-2152. doi:10.1093/brain/awg216
[16] Critchley, H.D., Wiens, S., Rotshtein, P., Ohman, A. and Dolan, R.J. (2004) Neural systems supporting interoceptive awareness, Nature Neuroscience, 7, 189-195. doi:10.1038/nn1176
[17] Bechara, A. and Naqvi, N. (2004) Listening to your heart: interoceptive awareness as a gateway to feeling, News and views, 7, 102-103. doi:10.1038/nn0204-102
[18] Matsunaga, M., Isowa, T., Kimura, K., Miyakoshi, M., Kanayama, N. and Murakami, H. et al. (2009) Associations among positive mood, brain, and cardiovascular activities in an affectively positive situation, Brain Research, 1263, 93-103. doi:10.1016/j.brainres.2009.01.027
[19] Iwase, M., Ouchi, Y., Okada, H., Yokoyama, C., Nobezawa, S. and Yoshikawa, E. et al. (2002) Neural substrates of human facial expression of pleasant emotion induced by comic films: a PET study, Neuroimage, 17, 758-768. doi:10.1006/nimg.2002.1225
[20] Bosch, J.A., Berntson, G.G., Cacioppo, J.T. and Marucha, P.T. (2005) Differential mobilization of functionally distinct natural killer subsets during acute psychological stress, Psychosomatic Medicine, 67, 366-375. doi:10.1097/01.psy.0000160469.00312.8e

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