Share This Article:

Chromatographic Separation and Characterization of Capsaicinoids and Their Analogues

Abstract Full-Text HTML Download Download as PDF (Size:411KB) PP. 136-140
DOI: 10.4236/pp.2011.23018    4,874 Downloads   8,943 Views   Citations

ABSTRACT

An attempt was made to establish a chromatographic separation and analysis method for capsaicinoids and their analogues. A series of factors,such as choice of column and eluents, eluent composition,flow rate of eluent and operational temperature were correlated, countereacted and optimized to attain appropriate separation efficiency and finalize the experimentally oprational procedures as a whole, permiting a mixture comprising 8 capsaicinoids including analogues to be separated and Characterized with an allowed deviations and within a period of 36 minutes via 1 test as well.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

J. Wang, L. Zhou, L. Wang, Z. Peng, S. Zhou, X. Zhou, X. Zhang and B. Peng, "Chromatographic Separation and Characterization of Capsaicinoids and Their Analogues," Pharmacology & Pharmacy, Vol. 2 No. 3, 2011, pp. 136-140. doi: 10.4236/pp.2011.23018.

References

[1] Wang Junlian, Peng Zhenghong, Zhang Xiaobin, Peng Bixian, A study of pungency of capsaicinoids as affected by their molecular structure alteration. Pharmacology and Pharmacy. in press.
[2] Mori, A., et al., Capsaicin, a component of red peppers, inhibits the growth of androgen-independent, p53 mutant prostate cancer cells. Cancer Research, 2006. 66(6): p. 3222-3229.
[3] Morre, D. J., et al., NADH oxidase activity from sera altered by capsaicin is widely distributed among cancer patients. Archives of Biochemistry and Biophysics, 1997. 342(2): p. 224-230.
[4] Sanchez, A. M., et al., Induction of the endoplasmic reticulum stress protein GADD153/CHOP by capsaicin in prostate PC-3 cells: A microarray study. Biochemical and Biophysical Research Communications, 2008. 372(4): p. 785-791.
[5] Malagarie-Cazenave, S., et al., Capsaicin, a component of red peppers, induces expression of androgen receptor via PI3K and MAPK pathways in prostate LNCaP cells. Febs Letters, 2009. 583(1): p. 141-147.
[6] Sanchez, A. M., et al., Apoptosis induced by capsaicin in prostate PC-3 cells involves ceramide accumulation, neutral sphingomyelinase, and JNK activation. Apoptosis, 2007. 12(11): p. 2013-2024.
[7] Brown, K. C., et al., Capsaicin Displays Anti-Prolifera- tive Activity against Human Small Cell Lung Cancer in Cell Culture and Nude Mice Models via the E2F Pathway. Plos One, 2010. 5(4): p. -.
[8] Ito, K., et al., Induction of apoptosis in leukemic cells by homovanillic acid derivative, capsaicin, through oxidative stress: Implication of phosphorylation of p53 at Ser-15 residue by reactive oxygen species. Cancer Research, 2004. 64(3): p. 1071-1078.
[9] Galati, G. and P.J. O'Brien, Cytoprotective and anticancer properties of coenzyme Q versus capsaicin. Biofactors, 2003. 18(1-4): p. 195-205.
[10] Diaz-Laviada, I., Effect of capsaicin on prostate cancer cells. Future Oncology, 2010. 6(10): p. 1545-1550.
[11] Kobata, K., et al., Enzymatic synthesis of capsaicin analogs with liver acetone powder. Tetrahedron Letters, 1996. 37(16): p. 2789-2790.

  
comments powered by Disqus

Copyright © 2019 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.