Synthesis of New Mannich Products Bearing Quinoline Nucleous Using Reusable Ionic Liquid and Antitubercular Evaluation

Hitendra M. Patel

Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, India.

DOI: 10.4236/gsc.2015.54017                

Abstract

A series of Mannich products bearing quinoline nucleus was synthesized, characterized, and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H₃₇Rv. The results showed that compounds 4b, and 4d found most active with percentage inhibition of 95, and 96, respectively, at minimum inhibitory concentration (MIC) of >6.25 μg/mL, among the synthesized compounds. Whereas, compounds 4a, 4c, 4e, and 4f exhibited considerable antitubercular activity with percentage inhibition of 71, 79, 55, and 68, respectively, at MIC of >6.25 μg/mL. The structures of synthesized compounds were elucidated by various spectroscopic tools like IR, ¹H NMR, ¹³C NMR, mass and elemental analysis.

Keywords

Antitubercular Activity, Green Synthesi, Mannich Products, Mycobacterium tuberculosis, Quinoline, Spectroscopic Tools

Conflicts of Interest

The authors declare no conflicts of interest.

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