The Effects of Xylitol on Body Weight Loss Management and Lipid Profile on Diet-Induced Obesity Mice


Xylitol is an alternative sweetener which has been previously reported to have many beneficial effects such as prevention from dental caries, reduction of visceral fat and increased synthesis of collagen. However, its role in body weight loss management has not been uncovered before. This study sought to investigate the effects of xylitol on body weight loss management, blood glucose and lipid profile on diet-induced obesity (DOI) mice. Fifteen male mice were subjected to high fat diet (60 kcal%) and normal drinking water for 28 days and then randomly divided into three (control, glucose and xylitol) groups. Each group of mice was then fed with normal diet for another 28 days with supplied normal drinking water (control); glucose solution 10% and xylitol solution 10%. Body weight loss was found to be significantly high in xylitol mice (2.56 ± 0.21, p = 0.003) compared to the other two groups. Lowest blood glucose level was found in the control group mice with the mean 7.65 ± 0.10 (p = 0.001). Xylitol mice had also showed the lowest total cholesterol level (4.20 ± 0.90, p = 0.000) than the other groups, but highest in HDL level (2.72 ± 0.14, p = 0.000). In conclusion, these findings proved that xylitol has the potential to reduce body weight, lowering the blood glucose but yet increase the HDL level.

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Ahmad, N. and Yusoff, N. (2015) The Effects of Xylitol on Body Weight Loss Management and Lipid Profile on Diet-Induced Obesity Mice. Journal of Biosciences and Medicines, 3, 54-58. doi: 10.4236/jbm.2015.310007.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Bray, G.A., et al. (2002) The Influence of Different Fats and Fatty Acids on Obesity, Insulin Resistance and Inflammation. The Journal of Nutrition, 132, 2488-2491.
[2] Skae, T. (2008) The Harmful Effects of Sugar and Choosing Healthy Alternatives.
[3] Amo, K., et al. (2011) Effects of Xylitol on Metabolic Parameters and Visceral Fat Accumulation. Journal of Clinical Biochemistry and Nutrition, 49, 1-7.
[4] Chukwuma, C.I. and Islam, M.S. (2015) Effects of Xylitol on Carbohydrate Digesting Enzymes Activity, Intestinal glucose Absorption and Muscle Glucose Uptake: A Multi-Mode Study. Food & Function, 6, 955-962.
[5] Islam, M.S. (2011) Effects of Xylitol as a Sugar Substitute on Diabetes-Related Parameters in Nondiabetic Rats. Journal of Medicinal Food, 14, 505-511.
[6] Salminen, S., Salminen, E., Koivistoinen, P., Bridges, J. and Marks, V. (1989) Gut Microflora Interactions with Xylitol in the Mouse, Rats and Men. Food and Chemical Toxicology, 23, 985-990.
[7] Sestoft, L. (1985) An Evaluation of Biochemical Aspects of Intravenous Fructose, Sorbitol and Xylitol Administration in Man. Acta Anaesthesiologica Scandinavica, 29, 19-29.
[8] Foerster, H., Meyer, E. and Ziege, M. (1972) Hepatische Glykogensynthese in Abaengigket von der Blutglucosekozentration Bein Narkotisierten Ratten. Wiener klinische Wochenschrift, 50, 478-480.
[9] Hessov, I. (1985) Which Carbohydrates Should We Recommend for Intravenous Nutrition? Acta Anaesthesiologica Scandinavica, 29, 30-31.
[10] Drews, D., et al. (1992) Effect of Excess Xylitol on Nitrogen and Glucose Metabolism in the Parenterally Fed Rats. Journal of Parenteral and Enteral Nutrition, 16, 521-524.
[11] Ardawi, M.S. (1992) Effects of Xylitol and/or Glutamine Supplemented Parenteral Nutrition on Septic Rats. Clinical Science, 82, 419-427.
[12] Tamura, M., Hoshi, C. and Hori, S. (2013) Xylitol Affects the Intestinal Microbiota and Metabolism of Daidzein in Adult Male Mice. International Journal of Molecular Sciences, 14, 23993-24007.
[13] Makinen, K.K. and Hamalainen, M.M. (1985) Metabolic Effects in Rats of High Oral Doses of Galactitol, Mannitol and Xylitol. Journal of Nutrition, 115, 890-899.

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