Synoptic Analysis of Epidemiologic Evidence of Glioma Risk from Mobile Phones


Concern about brain cancer risks from mobile phone use, in particular of glioma, is mainly based on epidemiologic studies reporting on an increased risk estimate (odds ratio, OR) in particular of long-term and/or heavy users. Concern is enhanced by contradictory results and alarming conclusions from some epidemiologic studies. In a new synoptic approach all reported data from epidemiological studies published since 2001 were analyzed. This approach provided new insight with regard to the suspected link between mobile phone use and glioma. Two quite different data pools could be identified with numerous studies from one single research group opposing all other national and international studies. It could be shown that in spite of puzzling differences of their data pattern, in dependence of the number of exposed cases both data pools exhibit the similar trend of ORs towards reduced glioma risk with increasing statistical power, finally even converging towards a reduced risk, although from either side of the zero-risk line. While in the pooled data a potential long-term risk could be masked by reassuring short-term data the synoptic analysis in dependence of dose surrogates such as cumulated use time, cumulated call time or cumulated number of calls the seemingly increased long-term risk of glioma could be identified as an effect from low statistical power. In spite of worrying differences among some epidemiological studies, overall, the synoptic analysis of the entire body of data supports reassuring rather than alarming conclusions on glioma risks from mobile phone use even in long-term and/or heavy users.

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Leitgeb, N. (2015) Synoptic Analysis of Epidemiologic Evidence of Glioma Risk from Mobile Phones. Journal of Electromagnetic Analysis and Applications, 7, 233-243. doi: 10.4236/jemaa.2015.79025.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] IARC (2011) IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Volume 102. Non-Ionizing Radiation, Part 2: Radio Frequency (RF) Electromagnetic Fields. Lyon, 2011.
[2] ICNIRP (1998) Guidelines for Limiting Exposure to Time-Varying Electric, Magnetic and Electromagnetic Fields (up to 300 GHz). Health Physics, 74, 494-522.
[3] IEEE (2005) IEEE Standard for Safety Levels with Respect to Human Exposure to Radio Frequency Electromagnetic Fields (up to 300GHz).
[4] Hardell, L. and Carlberg, M. (2013) Using the Hill Viewpoints from 1965 for Evaluating Strengths of Evidence of the Risk for Brain Tumors Associated with the Use of Mobile and Cordless Phones. Reviews on Environmental Health, 28, 97-106.
[5] Hardell, L., Carlberg, M., Söderqvist, F. and Hansson Mild, K. (2013) Case-Control Study of the Association between Malignant Brain Tumors between 2007 and 2009 and Mobile and Cordless Phone Use. International Journal of Oncology, 43, 1833-1845.
[6] Carlberg, M., Hansson Mild, K. and Hardell, L. (2013) Use of Mobile Phones and Cordless Phones Is Associated with Increased Risk for Glioma and Acoustic Neuroma. Pathophysiology, 20, 85-110.
[7] Hardell, L., Carlberg, M. and Hansson Mild, K. (2011) Pooled Analysis of Case-Control Studies on Malignant Brain Tumors and the Use of Mobile and Cordless Phones and Deceased Subjects. International Journal of Oncology, 38, 1465-1474.
[8] Hardell, L., Carlberg, M. and Hansson Mild, K. (2006) Pooled Analysis of Two Case-Control Studies on Use of Cellular and Cordless Telephones and the Risk for Malignant Brain Tumors Diagnosed in 1997-2003. International Archives of Occupational and Environmental Health, 79, 630-639.
[9] Hardell, L., Carlberg, M. and Hansson Mild, K. (2005) Use of Cellular Telephones and Brain Tumor Risk in Urban and Rural Areas. Occupational and Environmental Medicine, 62, 390-394.
[10] Leitgeb, N. (2014) Childhood Leukemia Not Linked with ELF Magnetic Fields. Journal of Electric and Magnetic Analysis and Applications, 6, 174-183.
[11] Leitgeb, N. (2014) Synoptic Analysis of Epidemiologic Evidence of Brain Cancer Risks from Mobile Communication. JEMAA, 6, 413-424.
[12] Interphone Study Group (2010) Brain Tumor Risk in Relation to Mobile Telephone Use: Results of the INTERPHONE International Case-Control Study. International Journal of Epidemiology, 39, 675-694.
[13] Coureau, G., Bouvier, G., Lebailly, P., Fabbro-Peray, P., Gruber, A., Leffondre, K., Guillamo J.-S., Loiseau, H., Mathoulin-Péklissier, S., Salamon, R. and Baldi, I. (2014) Mobile Phone Use and Brain Tumors in the CERENAT Case-Control Study. Occupational and Environmental Medicine, 71, 514-522.
[14] Swerdlow, A.J., Feychting, M., Green, A.C., Kheifets, L. and Savitz, D. (2011) Mobile Phones, Brain Tumors and the Interphone Study. Where Are We Now? Environmental Health Perspectives, 119, 1534-1538.
[15] Takebayashi, T., Varsier, N., Kikuchi, Y., Wake, K., Taki, M., Watanabe, S., Akiba, S. and Yamaguchi, N. (2008) Mobile Phone Use, Exposure to Radiofrequency Electromagnetic Field, and Brain Tumor. A Case-Control Study. British Journal of Cancer, 98, 652-659.
[16] Hours, M., Bernardt, M., Montestrucq, L., Arslan, M., Bergerer, A., Deltour, I. and Cardis, E. (2007) Cell Phones and Risk of Brain and Acoustic Nerve Tumors: The French INTERPHONE Case-Control Study. Revue d’Epidémiologie et de Santé Publique, 55, 321-332.
[17] Schlehofer, B., Schlaefer, K., Blettner, M., Berg, G., Böhler, E., Hetinger, I., Kunna-Grass, K., Wahrendorf, J. and Schüz, J. (2007) Environmental Risk Factors for Sporadic Acoustic Neuroma (Interphone Study Group Germany). European Journal of Cancer, 43, 1741-1747.
[18] Hepworth, S.J., Schoemaker, M.J., Muir, K.R., Swerdlow, A.J., van Tongeren, M.J. and McKinney, P.A. (2006) Mobile Phone Use and Risk of Glioma in Adults: Case-Control Study. BMJ, 332, 883-887.
[19] Klaeboe, L., Blaasaas, K.G. and Tynes, T. (2006) Use of Mobile Phones in Norway and Risk of Intracranial Tumors. European Journal of Cancer Prevention, 16, 158-164.
[20] Lahkola, A., Auvinen, A., Raitanen, J., Schoemaker, M.J., Christensen, H.C., Feychting, M., Johansen, C., Klaeboe, L., Lönn, S., Swerdlow, A.J., Tynes, T. and Salminen, T. (2006) Mobile Phones Use and Risk of Glioma in 5 North European Countries. International Journal of Cancer, 120, 1769-1775.
[21] Lönn, S., Ahlbom, A., Christensen, H.C., Johansen, C., Schüz, J., Edström, S., Henrikksson, G., Lundgren, J., Wennerberbg, J. and Feychting, M. (2006) Mobile Phone Use and Risk of Parotid Gland Tumor. American Journal of Epidemiology, 164, 637-643.
[22] Schüz, J., Böhler, E., Berg, G., Schlehofer, B., Hettinger, I., Schlaefer, K., Wahrendorf, J., Kunna-Grass, K. and Blettner, M. (2006) Cellular Phones, Cordless Phones and the Risk of Glioma and Meningioma (Interphone Study Group Germany). American Journal of Epidemiology, 163, 512-520.
[23] Lönn, S., Ahlbom, A., Hall, P. and Feychting, M. (2005) Long-Term Mobile Phone Use and Brain Tumor Risk. American Journal of Epidemiology, 161, 526-535.
[24] Auvinen, A., Hietanen, M., Luukkonen, R. and Koskela, R.S. (2002) Brain Tumors and Salivary Gland Cancers among Cellular Telephone Users. Epidemiology, 13, 356-359.
[25] Inskip, P.D., Tarone, R., Hatch, E., Wilcosky, T.C., Sjapiro, W.R., Selker, R.G., Fine, H.A., Black, P.M., Loeffler, J.S. and Kinet, M.S. (2001) Cellular Telephone Use and Brain Tumors. New England Journal of Medicine, 34, 79-86.
[26] Ahlbom, A., Feychting, M., Green, A., Kheifets, L., Savitz, D.A. and Swerdlow, A.J. (2009) Epidemiologic Evidence on Mobile Phone and Tumor Risk: A Review. Epidemiology, 20, 639-652.
[27] Kundi, M. (2009) The Controversy about a Possible Relationship between Mobile Phone Use and Cancer. Environmental Health Perspectives, 117, 306-324.
[28] Lagorio, S. and Röösli, M. (2014) Mobile Phone Use and Risk of Intracranial Tumors: A Consistency Analysis. Bioelectromagnetics, 35, 79-90.

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