The Effects of Antiretroviral Drugs on the Absorbance Characteristics of HIV-Infected Blood

Okwuchukwu Ani¹, Sam Omenyi², Chinonso Achebe^2*

¹Department of Mechanical and Production Engineering, Enugu State University of Science and Technology, Agbani, Nigeria.
²Department of Mechanical Engineering, Nnamdi Azikiwe University, Awka, Nigeria.

DOI: 10.4236/jbise.2015.89053                

Abstract

In the twenty first century research works, there may be a need to achieve a more reliable research result through a synergy between engineers and biological researchers. The peak absorbance data for various interacting systems were measured. These were used to show that the antiretroviral drug has the effect of increasing the peak absorbance values of both the uninfected and infected blood components, i.e., the drugs are made able to increase the light absorption capacity of the blood cells. For drug 2 that contains three components including Efavirenz, the drug effect on lymphocytes was increased by about 38% for patients that had been on antiretroviral drug treatment. Mathematical models were proposed and used in determining the coating effectiveness of antiretroviral drugs in the presence and absence of HIV. The use of the findings of this work by pharmaceutical industries may help in the search for more effective antiretroviral drugs for the treatment of HIV patients.

Keywords

Absorbance, Transmittance, Dielectric Constant, Human Immunodeficiency Virus, Antiretroviral Drug, Coating Effectiveness, Lymphocyte, Wavelength

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	Achebe, C.H. (2010) Human Immunodefficiency Virus (HIV)-Blood Interactions: Surface Thermodynamics Approach. Ph.D. Dissertation, Nnamdi Azikiwe University, Awka.
[2]	United States Department of Health and Human Services (2004) A Guide to Primary Care for People with HIV/AIDS, 2004 Edition. Washington DC.
[3]	Achebe, C.H. and Omenyi, S.N. (2013) The Effects of Human Immunodeficiency Virus (HIV) Infections on the Absorbance Characteristics of Different Blood Components. International Journal of Engineering and Science Invention, 2, 53-61. www.ijesi.org
[4]	Ekwuagana, E., (2014) Oral Communication. Tahilah Diagnostic Laboratories, Awka, Anambra State, Nigeria.
[5]	Ani, O.I. (2015) Surface Energetics Study of the Interactions between HIV and Blood Cells Treated with Antiretroviral Drugs. Ph.D. Dissertation, Nnamdi Azikiwe University, Awka.
[6]	Ozoihu, E.M. (2014) Human Immunodefficiency Virus (HIV)-Blood Interactions: Contact Angle Approach. PhD. Dissertation, Nnamdi Azikiwe University, Awka.
[7]	Achebe, C.H. and Omenyi, S.N. (2013) Mathematical Determination of the Critical Absolute Hamaker Constant of the Serum (as an Intervening Medium) Which Favours Repulsion in the Human Immunodeficiency Virus (HIV)-Blood Interactions Mechanism. Lecture Notes in Engineering and Computer Science. Proceedings of the World Congress on Engineering, WCE 2013, London, 3-5 July 2013, 1380-1384.