Primary Lymphoma of the Larynx: A Case Report and Literature Review

Khaled Khamassi¹, Madiha Mahfoudhi^2*, Habib Jaafoura¹, Khaoula Ouertani¹, Wafa Kaabachi¹, Lobna Bougacha¹, Rim Lahiani¹, Mamia Ben Salah¹

¹Department of Otorhinolaryngology—Head and Neck Surgery, Charles Nicolle Hospital, Tunis, Tunisia.
²Department of Internal Medicine A, Charles Nicolle Hospital, Tunis, Tunisia.

DOI: 10.4236/ojcd.2015.52015                

Abstract

Background: Primary non-hodgkin lymphoma of the larynx is a rare entity accounting for 1% of laryngeal tumors. Fewer than 100 cases have been reported in the literature. Case presentation: A 52-year-old man, presented with a two-month history of dysphonia. Nasofibroscopy showed left submucosal bulging of the laryngeal supraglottic floor. Cervical computed tomography showed extensive left supraglottic mass, with partial lysis of the thyroid cartilage. Direct laryngoscopy showed left submucosal bulging of the supraglottic floor. Transmucosal biopsies were performed. Histological study concluded to the presence of a diffuse large-cell B lymphoma. The patient was treated with chemotherapy followed by external radiotherapy. Evolution was favourable. Conclusion: Although primary laryngeal non-hodgkin lymphoma is rare, it should be considered in the differential diagnosis of a mass in the neck region, especially in the supraglottic area. Direct laryngoscopy with biopsy makes the diagnosis. Treatment and prognosis depend on the stage and the grade of the lymphoma.

Keywords

Larynx, Lymphoma, Laryngoscopy, Chemotherapy, Radiotherapy

Conflicts of Interest

The authors declare no conflicts of interest.

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