Low Doses of Rifampicin Used in New Tuberculosis Patients Correlated to Increased Frequency of Rifampicin-Resistance and Poorer Treatment Outcomes
Ling Chen1*, Jian Du2*, Liang Li2, Qi Li2, Qiu Zhong3, Yanyong Fu4, Bo Li5, Minggui Lin6, Liping Ma7, Youlun Li8, Xiaomeng Wang9, Yan Ma2, Xiaoying Jiang2, Xiaoyou Chen2, Qiping Ge2, Li Xie2, Xiqin Han2, Zhaogang Sun2, Guanglu Jiang2, Hong Zhang1,10*, Weiwei Gao2*
1Affiliated Hospital of Zunyi Medical College, Zunyi, China.
2Beijing Chest Hospital/Beijing Institute of Tuberculosis and Thoracic Tumor, Beijing, China.
3Guangdong Center for Tuberculosis Control, Guangzhou, China.
4Tianjin Center for Tuberculosis Control, Tianjin, China.
5Beijing Institute for Tuberculosis Control, Beijing, China.
6309th Hospital of PLA, Beijing, China.
7Henan Center for Disease Control, Zhengzhou, China.
8First Affiliated Hospital, Chongqing Medical University, Chongqing, China.
9Zhejiang Center for Disease Control, Hangzhou, China.
10Z-BioMed, Inc., Rockville, MD, USA.
DOI: 10.4236/ojmm.2015.52009   PDF   HTML   XML   4,016 Downloads   4,963 Views   Citations


The prognosis of patients with previously treated tuberculosis (TB) was suggested to be dependent on whether the initial treatment was in compliance with the established guidelines. The aim of this retrospective multicenter study was to determine the proportion of new TB patients who received standard doses of rifampicin in multiple provinces of China, and the relationship between low doses of rifampicin and frequency of rifampicin-resistance as well as treatment outcomes. A total of 713 new TB patients were treated with either once-daily dose of bulk anti-TB drugs (group I) or every other day combination blister packs of anti-TB drugs containing rifampicin (group II) at more than 30 TB treatment centers/hospitals in China. Treatment history, therapeutic doses of rifampicin, and information about patients were extracted from their medical records and analyzed, and rifampicin-resistance of isolates collected from patients following the treatment as well as treatment outcomes were compared between two treatment groups. Among 522 patients in treatment group I, 154 (29.5%) received standard and 363 (69.5%) received low doses of rifampicin; 238 (45.6%) isolates were rifampicin-resistant, and 243 (46.6%) were successfully treated. Among 191 patients in treatment group II, 175 (91.6%) received standard and 15 (7.9%) received low doses of rifampicin; 72 (37.7%) isolates were rifampicin-resistant, and 105 (55%) were successfully treated. When patients who received low doses of rifampicin were compared to others within the same treatment group, increased rates for rifampicin-resistance and treatment failure were observed. Results from this study showed that most new TB patients in treatment group I (69.5%) received low doses of rifampicin, and their treatment outcomes were worse than those in treatment group II, indicating that low doses of rifampicin used for the initial treatment of new TB patients were correlated to increased frequency of rifampicin-resistance and poorer treatment outcomes.

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Chen, L. , Du, J. , Li, L. , Li, Q. , Zhong, Q. , Fu, Y. , Li, B. , Lin, M. , Ma, L. , Li, Y. , Wang, X. , Ma, Y. , Jiang, X. , Chen, X. , Ge, Q. , Xie, L. , Han, X. , Sun, Z. , Jiang, G. , Zhang, H. and Gao, W. (2015) Low Doses of Rifampicin Used in New Tuberculosis Patients Correlated to Increased Frequency of Rifampicin-Resistance and Poorer Treatment Outcomes. Open Journal of Medical Microbiology, 5, 76-84. doi: 10.4236/ojmm.2015.52009.

Conflicts of Interest

The authors declare no conflicts of interest.


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