In Vivo Antiretroviral Effects of the Medicinal Synthetic Aluminum-Magnesium Silicate


Viral loads (copies of RNA per ml of plasma) of HIV/AIDS patients, who volunteered for clinical trial of the Medicinal synthetic Aluminum-magnesium silicate, were assessed, before and after they were treated. The treatment lasted 4 weeks, 8 weeks and 12 weeks respectively. A patient who could not access approved laboratory for viral load test on time, continued the treatment for 24 weeks. Following treatment with the medicine, mean viral load of HIV/AIDS patients reduced (P < 0.05) from 18875.00 ± 17059.18 to 327.50 ± 226.84. Rates of the viral load reduction were: 86% after 4 weeks, 96% after 8 weeks and 99.71% after 12 weeks. Clinical signs complained of, by the patients during the treatment, included, fever, dermatitis, boils, joint pain, leg edema and sore throat. These clinical signs ceased when they were treated, so that the antiretroviral treatment was completed. The patient who was on the medication for 24 weeks had no adverse drug reaction.

Share and Cite:

Ezeibe, M. and Ogbonna, I. (2015) In Vivo Antiretroviral Effects of the Medicinal Synthetic Aluminum-Magnesium Silicate. World Journal of AIDS, 5, 59-65. doi: 10.4236/wja.2015.52007.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Brooks, G.F. (1998) Medical Microbiology. 21st Edition, Mc Graw Hill Education Inc., San Franscisco.
[2] Vanderbilt Report (2012) Technical Information: “VEEGUM—The Versatile Ingredient for Pharmac-eutical Formulations. R.T. Vanderbilt Company Bulletin No. 91R, 1984. R.T. Vanderbilt Company, Inc., Norwalk.
[3] Cann, A.J. (1993) Principles of Molecular Biology. Academic Press, San Diego.
[4] Ezeibe, M.C.O. and Ogbonna, I.J. (2015) Acquired Immune Deficiency Syndrome in Man and Animals—A Review. World Journal of AIDS, 5, 50-57.
[5] Cristina, E., Ivan, P. and Kevin, R. (2007) Nanomaterials and Nanoparticles: Sources and Toxicity. Biointerphases, 2, MR17-MR71.
[6] Ezeibe, M.C.O., Ngene, A.A., Kalu, I.K., Ezeh, I.O., Mbuko, I.J., Ekwuruke, J.O., Anene, I., Amechi, B., Olowoniyi, P. and Ifekwe, I.F. (2014) Assessment of Antiretroviral Effects of a Synthetic Aluminum-Magnesium Silicate. BJMMR, 4, 1676-1679.
[7] HIV/AIDS: Where Did HIV Come from?
[8] Ezeibe, M.C.O. (2014) The Synthetic Aluminum-Magnesium Silicate (Nanoparticles). Federal Republic of Nigeria Patentsand Designs Act. Cap 344 LFN 1990, NO. NG/P/639.
[9] Murray, K.R. (2000) Harpers Biochemistry. McGraw Hill, New York.
[10] Ezeibe, M.C.O., Mbuko, I.J., Okoroafor, O.N., Okonkwo, A.C., Animoke, P.C., Orajaka, L.J.E. and Ngene, A.A. (2009) In Vitro and in Vivo Effects of Aluminium-Magnesium Silicate on Infectious Bursal Disease Virus in Chickens. Animal Science Reporter, 3, 132-137.
[11] Ezeibe, M.C.O., Ijabo, O., Okoroafor, O.N., Orajaka, L.J.E., Ukomadu, N.M. Chukwu, O.S. and Ngene, A.A. (2009) Antiviral Effects of Aluminum-Magnesium Silicate on Peste des Petits Ruminants Virus. Animal Science Reporter, 3, 141-147.
[12] Ezeibe, M.C.O., Okoroafor, O.N., Ijabo, O., Ukomadu, N.M., Ngene, A.A., Eze, J.I. and Orajaka, L.J.E. (2010) Haemagglutination and Haemagglutination Inhibition Titres of Egg Drop Syndrome 76 Virus Treated with Aluminium Magnesium Silicate. Animal Science Reporter, 4, 87-90.
[13] Ezeibe, M.C.O., Nwaogu, I.C., Nwaigwe, A.N., Okoroafor, O.N., Eze, J.I. and Ngene, A.A. (2010) Aluminium-Magnesium Silicate Inhibits Canine parvovirus and Cures Infected Dogs. Health, 2, 1215-1217.
[14] Ezeibe, M.C.O., Ijabo, O., Uzopuo, C., Okoroafor, O.N., Eze, J.I., Mbuko, I.J., Sanda, M.E., Animoke, P.C. and Ngene, A.A. (2011) Effects of Aluminium-Magnesium Silicate on Newcastle Disease Virus and on Recovery of Infected Chicks. International Journal of Biological and Chemical Sciences, 5, 825-829.
[15] Ezeibe, M.C.O., Egbuji, A.N., Eze, J.I., Ijabo, O., Ngene, A.A., Okoroafor, O.N., Eze, I.C., Ugonabo, J.A.C., Sanda, M.E. and Mbuko, I.J. (2012) Antiviral Effects of a Synthetic Aluminium-Magnesium Silicate on Avian Influenza Virus. Health, 4, 429-432.
[16] Ezeibe, M.C.O., Ekeanyanwu, E., Ngene, A.A. and Mbuko, I.J. (2013) Aluminum-Magnesium Silicate Enhances Release of Virions of Cultured Fowlpox Virus and Inhibits the Virus. Health, 5, 1394-1396.
[17] Ezeibe, M.C.O. (2014) Antiretroviral Effects of a Medicinal Synthetic Aluminum-Magnesium Silicate. Proceedings of the 1st Nigerian Research and Education Network Lecture Series.
[18] Ezeibe, M.C.O. (2006) Admacine®. Federal Republic of Nigeria Patents and Designs Act. Cap 344 LFN 1990, NO. RP 16446.
[19] McMichael, A.J. and Haynes, B.F. (2012) Lessons Learned from HIV-1 Vaccine Trials: New Priorities and Directions. Nature Immunology, 13, 423-427.
[20] Hladik, F. and McElrath, M.J. (2008) Setting the Stage: Host Invasion by HIV. Nature Reviews Immunology, 8, 447- 457.
[21] Joint United Nations Programme on HIV/AIDS and World Health Organization (2009) AIDS Epidemic Update. UNAIDS, Geneva, 21-22.
[22] Quinn, T.C. and Overbaugh, J. (2005) HIV/AIDS in Women: An Expanding Epidemic. Science, 308, 1582-1583.
[23] World Health Organization (2007) Laboratory Guidelines for Enumerating CD4 T Lymphocytes in the Context of HIV/AIDS. World Health Organization Regional Office for South-East Asia, New Delhi.
[24] Ezeibe, M.C.O., Okoye, J.O.A., Ogunniran, T.M., Animoke, P.C., Mbuko, I.J., Nwankwo, I.A. and Ngene, A.A. (2013) Mortality Rates from a Nigerian Isolate of the Infectious Bursa Disease Virus and Passive Haemagglutination Antibody Titer That Protects Chicks against Challenge with the Virus Isolate. Health, 5, 1355-1359.
[25] Ezeibe, M.C.O., Okoye, J.O.A., Ogunniran, T.M., Animoke, P.C., Ijeoma, J., Mbuko, I.J., Nwankwo, I.A. and Ngene, A.A. (2014) Effects of Live Infectious Bursa Disease Vaccines, on Immune Response of Vaccinated Chicks. BJMMR, 4, 1506-1513.
[26] Ezeibe, M.C.O., Ngene, A.A., Anene, I., Amechi, B., Olowoniyi, P., Eze, J.I. and Animoke, P.C. (2013) Direct Passive Hemagglutination Test for Rapid Quantification of Plasma Loads of the Human Immunodeficiency Virus. Health, 5, 1351-1354.
[27] Kaplan, R.M. (2002) Anthelmintic Resistance in Nematods of Horses. Veterinary Research, 33, 491-507.
[28] Ezeibe, M.C.O., Elendu-Eleke, N.P., Okoroafor, O.N. and Ngene, A.A. (2012) Adjuvant Effect of a Synthetic Aluminium-Magnesium Silicate on Chloroquine Phosphate, against Plasmodium berghei. Health, 4, 448-451.
[29] Ezeibe, M.C.O., Anosa, G.N., Okorie, O.K., Elendu-Eleke, N.P., Okoroafor, O.N, Ngene, A.A. and Chikelu, O.N. (2012) Aluminum-Magnesium Silicate Enhances Antibacterial Activity of Ampicilline Trihydrate, against S. gallinarum. Nature Proceedings.
[30] Ezeibe, M.C.O., Dire, C.D., Anosa, G.N., Chikelu, O.N., Okoroafor, O.N., Okorie, O.K., Ngene, A.A., Idika, I.K., Ogunniran, T.M. and Ezeala, I.E. (2012) Efficacy of Piperazine Citrate, Stabilized with Aluminum-Magnesium Silicate, against Helignosomoides bakeri. Health, 4, 890-892.
[31] Ezeibe, M.C.O., Chima, U.M., Ngene, A.A., Okoroafor, O.N., Kalu, I.I. and Esen, M.E. (2012) Effective Treatment of Resistant Escherichia coli Infection, with Sulphadimidine Stabilized in a Synthetic Aluminum-Magnesium Silicate. Health, 4, 1295-1298.
[32] Ezeibe, M.C.O., Ezeobele, O.K., Esen, M.E., Ngene, A.A., Mbuko, I.J., Chukwudi, I.C., Omoja, V.U. and Ezeh, I.O. (2013) Synergy in Antibacterial Activities of Ampicillin Trihydrate, Stabilized with a Synthetic Aluminum-Magnesium Silicate and Immune-Stimulants, on Resistant Escherichia coli Infection. Health, 5, 1548-1552.

Copyright © 2023 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.