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                    <a href='articles.aspx?searchcode=Mohamed+Mohamed++Adel+El-Sokkary&searchfield=authors&page=1' target='_blank'>Mohamed Mohamed  Adel El-Sokkary</a><sup>*</sup>, <a href='articles.aspx?searchcode=Eman+Salama++Abdelmegeed&searchfield=authors&page=1' target='_blank'>Eman Salama  Abdelmegeed</a><sup></sup> 

                </div>
            </div>
            <div id="JournalInfor_div_affs" style="float: left; margin-top: 10px; width: 100%;">
                <p style="font-size: 14px; font-weight: bold;">
                    <a name="abstract">
                        Affiliation(s)</a>
                </p>
                <div align="justify">
                    <a href='articles.aspx?searchcode=Microbiology+Department%2c+Faculty+of+Pharmacy%2c+Mansoura+University%2c+Mansoura%2c+Egypt&searchfield=affs&page=1&skid=0' target='_blank'>Microbiology Department, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt</a>.<br />
                </div>
            </div>
            <div style="float: left; margin-top: 10px; width: 100%;">
                <p style="font-size: 14px; font-weight: bold;">
                    <a name="abstract">
                        ABSTRACT</a>
                </p>
                <div style="text-align: justify; font-size: 13px;">
                    Extensive
use of antibacterials in clinical practice has been associated with increasing
frequency of multi-resistant <i>E.</i> <i>coli</i> strains. Genetic elements such as Class 1 integrons have an
important role in resistance development. In the current study, a total of 84 <i>E</i>. <i>coli</i> clinical isolates from
Mansoura hospitals patients in Egypt were screened for antibacterial
susceptibility against 12 different antibacterials. High resistance rates were
identified for Ampicillin (92.9%) and sulfamethoxazole/ trimethoprim (84.5%). Class
1 integron was investigated in <i>E. coli</i> isolates by PCR. As a result, Class 1 integron was identified in 51.2% of these
isolates. The contents of amplified integron varriable regions, were digested
by <i>Alu </i>I restriction endonuclease. Cluster analysis of Class 1 integron
digested varriable regions revealed that RFLP digested fragments generated could
be classified into 9 different patterns, namely A, B, C, D, E, F, G, H and I.
The most prevalent genotype was identifed in Group D. PCR and sequencing were
used for detection of antimicrobial resistance genes harbored in integrons of Group
D. As a result, main phylogenetic group identified harbored integron cassette carrying
resistance gene for two antimicrobial groups namely aminoglycoside and
trimethoprim. Multiresistance profiles in Group D exhibited association between
antimicrobial resistance and integron presence. These findings suggest that the
strategy for treatment of patients with <i>E. coli</i> infections needs to be
revised. Furthermore, the high prevalence of Class 1 integron carrying gene
confirms the importance of integron-mediated antimicrobial gene cassettes.
                </div>
            </div>
            <div id="JournalInfor_div_showkeywords" style="float: left; margin-top: 10px; width: 100%;">
                <p style="font-size: 14px; font-weight: bold;">
                    KEYWORDS
                </p>
                <div align="justify">
                    <a href='articles.aspx?searchcode=Integron&searchfield=keyword&page=1&skid=0' target='_blank'>Integron</a>, <a href='articles.aspx?searchcode=+Antimicrobial+Resistance&searchfield=keyword&page=1&skid=0' target='_blank'> Antimicrobial Resistance</a>, <a href='articles.aspx?searchcode=+E.+coli&searchfield=keyword&page=1&skid=0' target='_blank'> <i>E. coli</i></a>, <a href='articles.aspx?searchcode=+RFLP&searchfield=keyword&page=1&skid=0' target='_blank'> RFLP</a> 
                </div>
            </div>

            <div style="float: left; margin-top: 10px; width: 100%;">
                <p style="font-size: 14px; font-weight: bold;">
                    Cite this paper
                </p>
                <div align="justify">
                    Adel El-Sokkary, M.  and Abdelmegeed, E.   (2015) Characterisation of Class 1 Integron among <i>Escherichia coli</i> Isolated from Mansoura University Hospitals in Egypt. <i>Advances in Microbiology</i>, <b>5</b>, 269-277. doi: <a href='http://dx.doi.org/10.4236/aim.2015.54025' target='_blank' onclick='SetNum(55937)'>10.4236/aim.2015.54025</a>.
                </div>
            </div>

            <div style="float: left; margin-top: 10px; width: 100%;" id="htmlContent">
                
            </div>
            <div style="float: left; margin-top: 10px; width: 100%;">
                <p style="font-size: 14px; font-weight: bold;">Conflicts of Interest</p>
                <p style="text-align: justify;">
                    The authors declare no conflicts of interest.</p>
            </div>


            

            

            <div style="float: left; margin-top: 10px; width: 100%;">
                <p style="font-size: 14px; font-weight: bold;">
                    <a name="reference">
                        References</a>
                </p>
                <p>
                    <table width="100%" border="0" cellspacing="0" cellpadding="0" style="text-align: justify;">
                        
                                <tr>
                                    <td width="45" valign="top">

                                        [<a href='../reference/referencespapers.aspx?referenceid=1462459' target='_blank'>1</a>]
                                    </td>
                                    <td valign="top">
                                        <a target="_self" name="ref1" id="ref1"></a>
                                        Yang, H., et al. (2004) Characterization of Multiple-Antimicrobial-Resistant Escherichia coli Isolates from Diseased Chickens and Swine in China. Journal of Clinical Microbiology, 42, 3483-3489.<br/>http://dx.doi.org/10.1128/JCM.42.8.3483-3489.2004
                                    </td>
                                </tr>
                                <tr style="height: 15px;">
                                    <td colspan="2"></td>
                                </tr>
                            
                                <tr>
                                    <td width="45" valign="top">

                                        [<a href='../reference/referencespapers.aspx?referenceid=1462460' target='_blank'>2</a>]
                                    </td>
                                    <td valign="top">
                                        <a target="_self" name="ref2" id="ref2"></a>
                                        Barlow, R.S., et al. (2004) Isolation and Characterization of Integron-Containing Bacteria without Antibiotic Selection. Antimicrob Agents Chemother, 48, 838-842. <br/>http://dx.doi.org/10.1128/AAC.48.3.838-842.2004
                                    </td>
                                </tr>
                                <tr style="height: 15px;">
                                    <td colspan="2"></td>
                                </tr>
                            
                                <tr>
                                    <td width="45" valign="top">

                                        [<a href='../reference/referencespapers.aspx?referenceid=1462461' target='_blank'>3</a>]
                                    </td>
                                    <td valign="top">
                                        <a target="_self" name="ref3" id="ref3"></a>
                                        Zanetti, M.O., et al. (2013) Antimicrobial Resistance, Plasmids and Class 1 and 2 Integrons Occurring in Pseudomonas aeruginosa Isolated from Brazilian Aquatic Environments. Water Science and Technology, 67, 1144-1149.<br/>http://dx.doi.org/10.2166/wst.2013.676
                                    </td>
                                </tr>
                                <tr style="height: 15px;">
                                    <td colspan="2"></td>
                                </tr>
                            
                                <tr>
                                    <td width="45" valign="top">

                                        [<a href='../reference/referencespapers.aspx?referenceid=1462462' target='_blank'>4</a>]
                                    </td>
                                    <td valign="top">
                                        <a target="_self" name="ref4" id="ref4"></a>
                                        Lu, L., et al. (2010) Characterization of Antimicrobial Resistance and Integrons among Escherichia coli Isolated from Animal Farms in Eastern China. Acta Tropica, 113, 20-25. <br/>http://dx.doi.org/10.1016/j.actatropica.2009.08.028
                                    </td>
                                </tr>
                                <tr style="height: 15px;">
                                    <td colspan="2"></td>
                                </tr>
                            
                                <tr>
                                    <td width="45" valign="top">

                                        [<a href='../reference/referencespapers.aspx?referenceid=1462463' target='_blank'>5</a>]
                                    </td>
                                    <td valign="top">
                                        <a target="_self" name="ref5" id="ref5"></a>
                                        Olsson-Liljequist, B., et al. (1997) Antimicrobial Susceptibility Testing in Sweden. III. Methodology for Susceptibility Testing. Scandinavian Journal of Infectious Diseases. Supplementum, 105, 13-23.
                                    </td>
                                </tr>
                                <tr style="height: 15px;">
                                    <td colspan="2"></td>
                                </tr>
                            
                                <tr>
                                    <td width="45" valign="top">

                                        [<a href='../reference/referencespapers.aspx?referenceid=1462464' target='_blank'>6</a>]
                                    </td>
                                    <td valign="top">
                                        <a target="_self" name="ref6" id="ref6"></a>
                                        Fluit, A. and Schmitz, F. (1999) Class 1 Integrons, Gene Cassettes, Mobility, and Epidemiology. European Journal of Clinical Microbiology & Infectious Diseases, 18, 761-770. <br/>http://dx.doi.org/10.1007/s100960050398
                                    </td>
                                </tr>
                                <tr style="height: 15px;">
                                    <td colspan="2"></td>
                                </tr>
                            
                                <tr>
                                    <td width="45" valign="top">

                                        [<a href='../reference/referencespapers.aspx?referenceid=1462465' target='_blank'>7</a>]
                                    </td>
                                    <td valign="top">
                                        <a target="_self" name="ref7" id="ref7"></a>
                                        Lee, J.C., et al. (2001) The Prevalence of Trimethoprim-Resistance-Conferring Dihydrofolate Reductase Genes in Urinary Isolates of Escherichia coli in Korea. Journal of Antimicrobial Chemotherapy, 47, 599-604.<br/>http://dx.doi.org/10.1093/jac/47.5.599
                                    </td>
                                </tr>
                                <tr style="height: 15px;">
                                    <td colspan="2"></td>
                                </tr>
                            
                                <tr>
                                    <td width="45" valign="top">

                                        [<a href='../reference/referencespapers.aspx?referenceid=1462466' target='_blank'>8</a>]
                                    </td>
                                    <td valign="top">
                                        <a target="_self" name="ref8" id="ref8"></a>
                                        Nijssen, S., et al. (2005) Unnoticed Spread of Integron-Carrying Enterobacteriaceae in Intensive Care Units. Clinical Infectious Diseases, 41, 1-9. <br/>http://dx.doi.org/10.1086/430711
                                    </td>
                                </tr>
                                <tr style="height: 15px;">
                                    <td colspan="2"></td>
                                </tr>
                            
                                <tr>
                                    <td width="45" valign="top">

                                        [<a href='../reference/referencespapers.aspx?referenceid=1462467' target='_blank'>9</a>]
                                    </td>
                                    <td valign="top">
                                        <a target="_self" name="ref9" id="ref9"></a>
                                        Collis, C.M., et al. (2002) Integron-Encoded IntI Integrases Preferentially Recognize the Adjacent Cognate attI Site in Recombination with a 59-Be Site. Molecular Microbiology, 46, 1415-1427.<br/>http://dx.doi.org/10.1046/j.1365-2958.2002.03260.x
                                    </td>
                                </tr>
                                <tr style="height: 15px;">
                                    <td colspan="2"></td>
                                </tr>
                            
                                <tr>
                                    <td width="45" valign="top">

                                        [<a href='../reference/referencespapers.aspx?referenceid=1462468' target='_blank'>10</a>]
                                    </td>
                                    <td valign="top">
                                        <a target="_self" name="ref10" id="ref10"></a>
                                        Cambray, G., Guerout, A.M. and Mazel, D. (2010) Integrons. Annual Review of Genetics, 44, 141-166.<br/>http://dx.doi.org/10.1146/annurev-genet-102209-163504
                                    </td>
                                </tr>
                                <tr style="height: 15px;">
                                    <td colspan="2"></td>
                                </tr>
                            
                                <tr>
                                    <td width="45" valign="top">

                                        [<a href='../reference/referencespapers.aspx?referenceid=1462469' target='_blank'>11</a>]
                                    </td>
                                    <td valign="top">
                                        <a target="_self" name="ref11" id="ref11"></a>
                                        Navia, M.M., Ruiz, J. and Vila, J. (2004) Molecular Characterization of the Integrons in S higella Strains Isolated from Patients with Traveler’s Diarrhea. Diagnostic Microbiology and Infectious Disease, 48, 175-179.<br/>http://dx.doi.org/10.1016/j.diagmicrobio.2003.10.007
                                    </td>
                                </tr>
                                <tr style="height: 15px;">
                                    <td colspan="2"></td>
                                </tr>
                            
                                <tr>
                                    <td width="45" valign="top">

                                        [<a href='../reference/referencespapers.aspx?referenceid=1462470' target='_blank'>12</a>]
                                    </td>
                                    <td valign="top">
                                        <a target="_self" name="ref12" id="ref12"></a>
                                        Mathai, E., Grape, M. and Kronvall, G. (2004) Integrons and Multidrug Resistance among Escherichia coli Causing Community-Acquired Urinary Tract Infection in Southern India. APMIS, 112, 159-164.<br/>http://dx.doi.org/10.1111/j.1600-0463.2004.apm1120301.x
                                    </td>
                                </tr>
                                <tr style="height: 15px;">
                                    <td colspan="2"></td>
                                </tr>
                            
                                <tr>
                                    <td width="45" valign="top">

                                        [<a href='../reference/referencespapers.aspx?referenceid=1462471' target='_blank'>13</a>]
                                    </td>
                                    <td valign="top">
                                        <a target="_self" name="ref13" id="ref13"></a>
                                        Rijavec, M., Erjavec, M.S., Avgustin, J.A., Reissbrodt, R., Fruth, A., Krizan-Hergouth, V. and Zgur-Bertok, D. (2006) High Prevalence of Multidrug Resistance and Random Distribution of Mobile Genetic Elements among Uropathogenic Escherichia coli (UPEC) of the Four Major Phylogenetic Groups. Current Microbiology, 53, 158-162.<br/>http://dx.doi.org/10.1007/s00284-005-0501-4
                                    </td>
                                </tr>
                                <tr style="height: 15px;">
                                    <td colspan="2"></td>
                                </tr>
                            
                                <tr>
                                    <td width="45" valign="top">

                                        [<a href='../reference/referencespapers.aspx?referenceid=1462472' target='_blank'>14</a>]
                                    </td>
                                    <td valign="top">
                                        <a target="_self" name="ref14" id="ref14"></a>
                                        Yu, H.S., Lee, J.C., Kang, H.Y., Ro, D.W., Chung, J.Y., Jeong, Y.S., et al. (2003) Changes in Gene Cassettes of Class 1 Integrons among Escherichia coli Isolates from Urine Specimens Collected in Korea during the Last Two Decades. Journal of Clinical Microbiology, 41, 5429-5433. <br/>http://dx.doi.org/10.1128/JCM.41.12.5429-5433.2003
                                    </td>
                                </tr>
                                <tr style="height: 15px;">
                                    <td colspan="2"></td>
                                </tr>
                            
                                <tr>
                                    <td width="45" valign="top">

                                        [<a href='../reference/referencespapers.aspx?referenceid=1462473' target='_blank'>15</a>]
                                    </td>
                                    <td valign="top">
                                        <a target="_self" name="ref15" id="ref15"></a>
                                        Rao, A.N., Barlow, M., Clark, L.A., Boring, J.R., Tenover, F.C. and McGowan, J.E. (2006) Class 1 Integrons in Resistant Escherichia coli and Klebsiella spp., US Hospitals. Emerging Infectious Diseases, 12, 1011-1014.<br/>http://dx.doi.org/10.3201/eid1206.051596
                                    </td>
                                </tr>
                                <tr style="height: 15px;">
                                    <td colspan="2"></td>
                                </tr>
                            
                                <tr>
                                    <td width="45" valign="top">

                                        [<a href='../reference/referencespapers.aspx?referenceid=1462474' target='_blank'>16</a>]
                                    </td>
                                    <td valign="top">
                                        <a target="_self" name="ref16" id="ref16"></a>
                                        Ibrahim, M.E., Magzoub, M.A., Bilal, N.E. and Hamid, M.E. (2013) Distribution of Class I Integrons and Their Effect on the Prevalence of Multi-Drug Resistant Escherichia coli Clinical Isolates from Sudan. Saudi Medical Journal, 34, 240-247.
                                    </td>
                                </tr>
                                <tr style="height: 15px;">
                                    <td colspan="2"></td>
                                </tr>
                            
                                <tr>
                                    <td width="45" valign="top">

                                        [<a href='../reference/referencespapers.aspx?referenceid=1462475' target='_blank'>17</a>]
                                    </td>
                                    <td valign="top">
                                        <a target="_self" name="ref17" id="ref17"></a>
                                        Roe, M.T., Vega, E. and Pillai, S.D. (2003) Antimicrobial Resistance Markers of Class 1 and Class 2 Integron-Bearing Escherichia coli from Irrigation Water and Sediments. Emerging Infectious Diseases, 9, 822-826.<br/>http://dx.doi.org/10.3201/eid0907.020529
                                    </td>
                                </tr>
                                <tr style="height: 15px;">
                                    <td colspan="2"></td>
                                </tr>
                            
                                <tr>
                                    <td width="45" valign="top">

                                        [<a href='../reference/referencespapers.aspx?referenceid=1462476' target='_blank'>18</a>]
                                    </td>
                                    <td valign="top">
                                        <a target="_self" name="ref18" id="ref18"></a>
                                        Crichton, P. (1996) Enterobacteriaceae: Escherichia, Klebsiella, Proteus and Other Genera. In: Collee, J.G., Fraser, A.G., Marmion, B.P. and Simmons, A., Eds., Mckie and Maccarney Practical Medical Microbiology, 14th Edition, Churchill Living-Stone, Ebionburgh.
                                    </td>
                                </tr>
                                <tr style="height: 15px;">
                                    <td colspan="2"></td>
                                </tr>
                            
                                <tr>
                                    <td width="45" valign="top">

                                        [<a href='../reference/referencespapers.aspx?referenceid=1462477' target='_blank'>19</a>]
                                    </td>
                                    <td valign="top">
                                        <a target="_self" name="ref19" id="ref19"></a>
                                        NCCLS (2004) National Committee for Clinical Laboratory Standards. Performance Standards for Antimicrobial Disk and Dilution Susceptibility Tests for Bacteria: Approved Standard M31-A2. NCCLS, Wayne.
                                    </td>
                                </tr>
                                <tr style="height: 15px;">
                                    <td colspan="2"></td>
                                </tr>
                            
                                <tr>
                                    <td width="45" valign="top">

                                        [<a href='../reference/referencespapers.aspx?referenceid=1462478' target='_blank'>20</a>]
                                    </td>
                                    <td valign="top">
                                        <a target="_self" name="ref20" id="ref20"></a>
                                        Roe, M.T., Vega, E. and Pillai, S.D. (2003) Antimicrobial Resistance Markers of Class 1 and Class 2 Integron-Bearing Escherichia coli from Irrigation Water and Sediments. Emerging Infectious Diseases, 9, 822-826.
                                    </td>
                                </tr>
                                <tr style="height: 15px;">
                                    <td colspan="2"></td>
                                </tr>
                            
                                <tr>
                                    <td width="45" valign="top">

                                        [<a href='../reference/referencespapers.aspx?referenceid=1462479' target='_blank'>21</a>]
                                    </td>
                                    <td valign="top">
                                        <a target="_self" name="ref21" id="ref21"></a>
                                        Ochman, H., Lawrence, J.G. and Groisman, E.A. (2000) Lateral Gene Transfer and the Nature of Bacterial Innovation. Nature, 405, 299-304.
                                    </td>
                                </tr>
                                <tr style="height: 15px;">
                                    <td colspan="2"></td>
                                </tr>
                            
                                <tr>
                                    <td width="45" valign="top">

                                        [<a href='../reference/referencespapers.aspx?referenceid=1462480' target='_blank'>22</a>]
                                    </td>
                                    <td valign="top">
                                        <a target="_self" name="ref22" id="ref22"></a>
                                        Hall, R.M. and Collis, C.M. (1998) Antibiotic Resistance in Gram-Negative Bacteria: The Role of Gene Cassettes and Integrons. Drug Resistance Updates, 1, 109-119. <br/>http://dx.doi.org/10.1016/S1368-7646(98)80026-5
                                    </td>
                                </tr>
                                <tr style="height: 15px;">
                                    <td colspan="2"></td>
                                </tr>
                            
                                <tr>
                                    <td width="45" valign="top">

                                        [<a href='../reference/referencespapers.aspx?referenceid=1462481' target='_blank'>23</a>]
                                    </td>
                                    <td valign="top">
                                        <a target="_self" name="ref23" id="ref23"></a>
                                        Japoni, A., Gudarzi, M., Farshad, S., Basiri, E., Ziyaeyan, M., Alborzi, A. and Rafaatpour, N. (2008) Assay for Integrons and Pattern of Antibiotic Resistance in Clinical Escherichia coli Strains by PCR-RFLP in Southern Iran. Japanese Journal of Infectious Diseases, 61, 85-88.
                                    </td>
                                </tr>
                                <tr style="height: 15px;">
                                    <td colspan="2"></td>
                                </tr>
                            
                                <tr>
                                    <td width="45" valign="top">

                                        [<a href='../reference/referencespapers.aspx?referenceid=1462482' target='_blank'>24</a>]
                                    </td>
                                    <td valign="top">
                                        <a target="_self" name="ref24" id="ref24"></a>
                                        Tariq, N., Jaffery, T., Ayub, R., Alam, A.Y., Javid, M.H. and Shafique, S. (2006) Frequency and Antimicrobial Susceptibility of Aerobic Bacterial Vaginal Isolates. Journal of the College of Physicians and Surgeons Pakistan, 16, 196-199.
                                    </td>
                                </tr>
                                <tr style="height: 15px;">
                                    <td colspan="2"></td>
                                </tr>
                            
                                <tr>
                                    <td width="45" valign="top">

                                        [<a href='../reference/referencespapers.aspx?referenceid=1462483' target='_blank'>25</a>]
                                    </td>
                                    <td valign="top">
                                        <a target="_self" name="ref25" id="ref25"></a>
                                        Gulsun, S., Oguzoglu, N., Inan, A. and Ceran, N. (2005) The Virulence Factors and Antibiotic Sensitivities of Escherichia coli Isolated from Recurrent Urinary Tract Infections. Saudi Medical Journal, 26, 1755-1758.
                                    </td>
                                </tr>
                                <tr style="height: 15px;">
                                    <td colspan="2"></td>
                                </tr>
                            
                                <tr>
                                    <td width="45" valign="top">

                                        [<a href='../reference/referencespapers.aspx?referenceid=1462484' target='_blank'>26</a>]
                                    </td>
                                    <td valign="top">
                                        <a target="_self" name="ref26" id="ref26"></a>
                                        Sahm, D.F., Thornsberry, C., Mayfield, D.C., Jones, M.E. and Karlowsky, J.A. (2001) Multidrug-Resistant Urinary Tract Isolates of Escherichia coli: Prevalence and Patient Demographics in the United States in 2000. Antimicrobial Agents and Chemotherapy, 45, 1402-1406. <br/>http://dx.doi.org/10.1128/AAC.45.5.1402-1406.2001
                                    </td>
                                </tr>
                                <tr style="height: 15px;">
                                    <td colspan="2"></td>
                                </tr>
                            
                                <tr>
                                    <td width="45" valign="top">

                                        [<a href='../reference/referencespapers.aspx?referenceid=1462485' target='_blank'>27</a>]
                                    </td>
                                    <td valign="top">
                                        <a target="_self" name="ref27" id="ref27"></a>
                                        Mazel, D. (2006) Integrons: Agents of Bacterial Evolution. Nature Reviews Microbiology, 4, 608-620.<br/>http://dx.doi.org/10.1038/nrmicro1462
                                    </td>
                                </tr>
                                <tr style="height: 15px;">
                                    <td colspan="2"></td>
                                </tr>
                            
                                <tr>
                                    <td width="45" valign="top">

                                        [<a href='../reference/referencespapers.aspx?referenceid=1462486' target='_blank'>28</a>]
                                    </td>
                                    <td valign="top">
                                        <a target="_self" name="ref28" id="ref28"></a>
                                        Karczmarczyk, M., Walsh, C., Slowey, R., Leonard, N. and Fanning, S. (2011) Molecular Characterization of Multidrug-Resistant Escherichia coli Isolates from Irish Cattle Farms. Applied and Environmental Microbiology, 77, 7121-7127. <br/>http://dx.doi.org/10.1128/AEM.00601-11
                                    </td>
                                </tr>
                                <tr style="height: 15px;">
                                    <td colspan="2"></td>
                                </tr>
                            
                                <tr>
                                    <td width="45" valign="top">

                                        [<a href='../reference/referencespapers.aspx?referenceid=1462487' target='_blank'>29</a>]
                                    </td>
                                    <td valign="top">
                                        <a target="_self" name="ref29" id="ref29"></a>
                                        Leverstein-Van Hall, M.A., Paauw, A., Box, A.T., Blok, H.E., Verhoef, J. and Fluit, A.C. (2002) Presence of Integron-Associated Resistance in the Community Is Widespread and Contributes to Multidrug Resistance in the Hospital. Journal of Clinical Microbiology, 40, 3038-3040. <br/>http://dx.doi.org/10.1128/JCM.40.8.3038-3040.2002
                                    </td>
                                </tr>
                                <tr style="height: 15px;">
                                    <td colspan="2"></td>
                                </tr>
                            
                                <tr>
                                    <td width="45" valign="top">

                                        [<a href='../reference/referencespapers.aspx?referenceid=1462488' target='_blank'>30</a>]
                                    </td>
                                    <td valign="top">
                                        <a target="_self" name="ref30" id="ref30"></a>
                                        Gassama, A., Aidara-Kane, A., Chainier, D., Denis, F. and Ploy, M.C. (2004) Integron-Associated Antibiotic Resistance in Enteroaggregative and Enteroinvasive Escherichia coli. Microbial Drug Resistance, 10, 27-30.<br/>http://dx.doi.org/10.1089/107662904323047763
                                    </td>
                                </tr>
                                <tr style="height: 15px;">
                                    <td colspan="2"></td>
                                </tr>
                            
                                <tr>
                                    <td width="45" valign="top">

                                        [<a href='../reference/referencespapers.aspx?referenceid=1462489' target='_blank'>31</a>]
                                    </td>
                                    <td valign="top">
                                        <a target="_self" name="ref31" id="ref31"></a>
                                        Su, J.Y., Shi, L., Yang, L.S., Xiao, Z.H., Li, X.H. and Yamasaki, S. (2006) Analysis of Integrons in Clinical Isolates of Escherichia coli in China during the Last Six Years. FEMS Microbiology Letters, 254, 75-80.<br/>http://dx.doi.org/10.1111/j.1574-6968.2005.00025.x
                                    </td>
                                </tr>
                                <tr style="height: 15px;">
                                    <td colspan="2"></td>
                                </tr>
                            
                                <tr>
                                    <td width="45" valign="top">

                                        [<a href='../reference/referencespapers.aspx?referenceid=1462490' target='_blank'>32</a>]
                                    </td>
                                    <td valign="top">
                                        <a target="_self" name="ref32" id="ref32"></a>
                                        Zhang, H.M., Shi, L., Li, L., Guo, S.Y., Zhang, X.M., Yamasaki, S., et al. (2004) Identification and Characterization of Class 1 Integron Resistance Gene Cassettes among Salmonella Strains Isolated from Healthy Humans in China. Microbiology and Immunology, 48, 639-645. <br/>http://dx.doi.org/10.1111/j.1348-0421.2004.tb03473.x
                                    </td>
                                </tr>
                                <tr style="height: 15px;">
                                    <td colspan="2"></td>
                                </tr>
                            
                                <tr>
                                    <td width="45" valign="top">

                                        [<a href='../reference/referencespapers.aspx?referenceid=1462491' target='_blank'>33</a>]
                                    </td>
                                    <td valign="top">
                                        <a target="_self" name="ref33" id="ref33"></a>
                                        Chang, L.L., Chang, T.M. and Chang, C.Y. (2007) Variable Gene Cassette Patterns of Class 1 Integron-Associated Drug-Resistant Escherichia coli in Taiwan. Kaohsiung Journal of Medical Sciences, 23, 273-280.<br/>http://dx.doi.org/10.1016/S1607-551X(09)70409-7
                                    </td>
                                </tr>
                                <tr style="height: 15px;">
                                    <td colspan="2"></td>
                                </tr>
                            
                                <tr>
                                    <td width="45" valign="top">

                                        [<a href='../reference/referencespapers.aspx?referenceid=1462492' target='_blank'>34</a>]
                                    </td>
                                    <td valign="top">
                                        <a target="_self" name="ref34" id="ref34"></a>
                                        Kang, H.Y., Jeong, Y.S., Oh, J.Y., Tae, S.H., Choi, C.H., Moon, D.C., et al. (2005) Characterization of Antimicrobial Resistance and Class 1 Integrons Found in Escherichia coli Isolates from Humans and Animals in Korea. Journal of Antimicrobial Chemotherapy, 55, 639-644. <br/>http://dx.doi.org/10.1093/jac/dki076
                                    </td>
                                </tr>
                                <tr style="height: 15px;">
                                    <td colspan="2"></td>
                                </tr>
                            
                                <tr>
                                    <td width="45" valign="top">

                                        [<a href='../reference/referencespapers.aspx?referenceid=1462493' target='_blank'>35</a>]
                                    </td>
                                    <td valign="top">
                                        <a target="_self" name="ref35" id="ref35"></a>
                                        Lindstedt, B.A., Heir, E., Nygard, I. and Kapperud, G. (2003) Characterization of Class I Integrons in Clinical Strains of Salmonella enterica Subsp. enterica Serovars Typhimurium and Enteritidis from Norwegian Hospitals. Journal of Medical Microbiology, 52, 141-149. <br/>http://dx.doi.org/10.1099/jmm.0.04958-0
                                    </td>
                                </tr>
                                <tr style="height: 15px;">
                                    <td colspan="2"></td>
                                </tr>
                            
                                <tr>
                                    <td width="45" valign="top">

                                        [<a href='../reference/referencespapers.aspx?referenceid=1462494' target='_blank'>36</a>]
                                    </td>
                                    <td valign="top">
                                        <a target="_self" name="ref36" id="ref36"></a>
                                        Nógrády, N., Gadó, I., Tóth, A. and Pászti, J. (2005) Antibiotic Resistance and Class 1 Integron Patterns of Non-Typhoidal Human Salmonella Serotypes Isolated in Hungary in 2002 and 2003. International Journal of Antimicrobial Agents, 26, 126-132. <br/>http://dx.doi.org/10.1016/j.ijantimicag.2005.04.015
                                    </td>
                                </tr>
                                <tr style="height: 15px;">
                                    <td colspan="2"></td>
                                </tr>
                            
                                <tr>
                                    <td width="45" valign="top">

                                        [<a href='../reference/referencespapers.aspx?referenceid=1462495' target='_blank'>37</a>]
                                    </td>
                                    <td valign="top">
                                        <a target="_self" name="ref37" id="ref37"></a>
                                        Petersen, A., Guardabassi, L., Dalsgaard, A. and Olsen, J.E. (2000) Class I Integrons Containing a dhfrI Trimethoprim Resistance Gene Cassette in Aquatic Acinetobacter spp. FEMS Microbiology Letters, 182, 73-76.<br/>http://dx.doi.org/10.1111/j.1574-6968.2000.tb08876.x
                                    </td>
                                </tr>
                                <tr style="height: 15px;">
                                    <td colspan="2"></td>
                                </tr>
                            
                                <tr>
                                    <td width="45" valign="top">

                                        [<a href='../reference/referencespapers.aspx?referenceid=1462496' target='_blank'>38</a>]
                                    </td>
                                    <td valign="top">
                                        <a target="_self" name="ref38" id="ref38"></a>
                                        O’Brien, T.F. (2002) Emergence, Spread, and Environmental Effect of Antimicrobial Resistance: How Use of an Antimicrobial Anywhere Can Increase Resistance to Any Antimicrobial Anywhere Else. Clinical Infectious Diseases, 34, S78-S84. <br/>http://dx.doi.org/10.1086/340244
                                    </td>
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