Functional Dyspepsia and Chronic Gastritis Associated with Enteroviruses

John K. Chia; Andrew Y. Chia; David Wang; Rabiha El-Habbal

doi:10.4236/ojgas.2015.54005

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OJGas> Vol.5 No.4, April 2015

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Functional Dyspepsia and Chronic Gastritis Associated with Enteroviruses

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DOI: 10.4236/ojgas.2015.54005 4,339 Downloads 6,160 Views Citations

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John K. Chia^*, Andrew Y. Chia, David Wang, Rabiha El-Habbal

Affiliation(s)

EV Med Research LLC, Lomita, USA.

ABSTRACT

After decades of research, functional dyspepsia (FD) remains one of the most elusive gastrointestinal disorders. Endoscopic appearance of mild inflammation of the gastric mucosa without ulceration and microscopic evidence of mild chronic inflammation are often considered as normal findings since no etiology could be found other than H. Pylori. Enteroviruses infect the gastrointestinal tract and have been shown to persist in the stomach of symptomatic patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). In this study, we evaluated FD patients with and without the diagnosis of ME/CFS, and were able to support the viral protein staining with finding of double-stranded RNA in 63% of the same stomach biopsies by immunoperoxidase staining. Furthermore, we clarified the possible cross-reaction with creatine kinase brain subtype (CK_B), present in parietal cells, using antibody competition experiments and western blot analysis of stomach proteins. Viral protein+ and dsRNA+ biopsies were infectious in SCID mice. More research is needed to elucidate the mechanism of enterovirus infection of the stomach associated with FD and chronic gastritis.

KEYWORDS

Functional Dyspepsia, Chronic Gastritis, Enterovirus, Double Stranded RNA

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Chia, J. , Chia, A. , Wang, D. and El-Habbal, R. (2015) Functional Dyspepsia and Chronic Gastritis Associated with Enteroviruses. Open Journal of Gastroenterology, 5, 21-27. doi: 10.4236/ojgas.2015.54005.

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