On the Inverse MEG Problem with a 1-D Current Distribution

Abstract

The inverse problem of magnetoencephalography (MEG) seeks the neuronal current within the conductive brain that generates a measured magnetic flux in the exterior of the brain-head system. This problem does not have a unique solution, and in particular, it is not even possible to identify the support of the current if it extends over a three-dimensional set. However, a localized current supported on a zero-, one- or two-dimensional set can in principle be identified. In the present work, we demonstrate an analytic algorithm that is able to recover a one-dimensional distribution of current from the knowledge of the exterior magnetic flux field. In particular, we consider a neuronal current that is supported on a small line segment of arbitrary location and orientation in space, and we reduce the identification of its characteristics to a nonlinear algebraic system. A series of numerical tests show that this system has a unique real solution. A special case is easily solved via the use of trivial algebraic operations.

Share and Cite:

Dassios, G. and Satrazemi, K. (2015) On the Inverse MEG Problem with a 1-D Current Distribution. Applied Mathematics, 6, 95-105. doi: 10.4236/am.2015.61010.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] Hamalainen, M., Hari, R., Ilmoniemi, R.J., Knuutila, J. and Lounasmaa, O. (1993) Magnetoencephalography—Theory, Instrumentation, and Applications to Noninvasive Studies of the Working Human Brain. Reviews of Modern Physics, 65, 413.
http://dx.doi.org/10.1103/RevModPhys.65.413
[2] Malmivuo, J. and Plonsey, R. (1995) Bioelectromagnetism. Oxford University Press, New York.
[3] Helmholtz, H. (1853) Ueber einige Gesetze der Vertheilung elektrischer Str ome in k orperlichen Leitern mit Anwendung auf die thierisch-elektrischen Versuche. Annalen der Physik und Chemie, 89, 211-233, 353-377.
[4] Dassios, G. and Fokas, A.S. (2013) The Definitive Non Uniqueness Results for Deterministic EEG and MEG Data. Inverse Problems, 29, 1-10.
http://dx.doi.org/10.1088/0266-5611/29/6/065012
[5] Albanese, R. and Monk, P.B. (2006) The Inverse Source Problem for Maxwell’s Equations. Inverse Problems, 22, 1023-1035.
http://dx.doi.org/10.1088/0266-5611/22/3/018
[6] Landau, L.D. and Lifshitz, E.M. (1960) Electrodynamics of Continuous Media. Pergamon Press, London.
[7] Plonsey, R. and Heppner, D.B. (1967) Considerations of Quasi-Stationarity in Electrophysiological Systems. Bulletin of Mathematical Biophysics, 29, 657-664.
http://dx.doi.org/10.1007/BF02476917
[8] Sarvas, J. (1987) Basic Mathematical and Electromagnetic Concepts of the Biomagnetic Inverse Problems. Physics in Medicine and Biology, 32, 11-22.
http://dx.doi.org/10.1088/0031-9155/32/1/004
[9] Geselowitz, D.B. (1970) On the Magnetic Field Generated outside an Inhomogeneous Volume Conductor by Internal Current Sources. IEEE Transactions in Biomagnetism, 6, 346-347.
http://dx.doi.org/10.1109/TMAG.1970.1066765
[10] Dassios, G. (2009) Electric and Magnetic Activity of the Brain in Spherical and Ellipsoidal Geometry. Mathematical Modeling in Biomedical Imaging I Lecture Notes in Mathematics, 133-202.
[11] Dassios, G. (2012) Ellipsoidal Harmonics. Theory and Applications. Cambridge University Press, Cambridge.
http://dx.doi.org/10.1017/CBO9781139017749
[12] Dassios, G. and Fokas, A.S. (2009) Electro-Magneto-Encephalography and Fundamental Solutions. Quarterly of Applied Mathematics, 67, 771-780.
[13] Dassios, G. and Fokas, A.S. (2009) Electro-Magneto-Encephalography for the Three-Shell Model: Dipoles and Beyond for the Spherical Geometry. Inverse Problems, 25, Article ID: 035001.
http://dx.doi.org/10.1088/0266-5611/25/3/035001
[14] Morse, P.M. and Feshbach, H. (1953) Methods of Theoretical Physics, Volume I. McGraw-Hill, New York.
[15] Brand, L. (1947) Vector and Tensor Analysis. John Wiley and Sons, New York.

Copyright © 2023 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.