Magnetic Field Configurations Corresponding to Electric Field Patterns That Evoke Long-Term Potentiation Shift Power Spectra of Light Emissions from Microtubules from Non-Neural Cells


Photon counts were measured every 15 ms for 75 s from microtubule-enriched preparations (and nuclei) from mouse melanoma cells during baseline and after 2 min exposures to 1 μT magnetic fields. The magnetic fields were generated from a circular array of solenoids and presented with accelerating or decelerating rotation velocities. The range of photon radiant flux density was in the order of 10-12 W·m-2. Microtubules preparations that had been exposed for only 2 min to a magnetic field configuration corresponding to the electric field pattern that induced long-term potentiation in neural tissue when applied as electric current displayed peaks of spectral power densities within 7 - 8 Hz, 9.5 Hz, 14 - 15 Hz, and 22 Hz bands. The major peak (9.4 Hz) bandwidth was approximately 0.1 Hz. While microtubule preparations exposed for 2 min to a 7 Hz sine-wave or in the absence of a field emitted an overall similar level of spectral power density, the peaks in power density were not present. Treatment with the LTP patterned fields, compared to the baseline or sine-wave fields primarily altered the frequency band in which the amplitude of the photon field was expressed. These results suggest that the photon emissions from microtubule preparations have the capacity to respond to specifically-patterned or geometric shapes of magnetic fields by altering spectral configurations rather than the absolute numbers of photons.

Share and Cite:

Dotta, B. , Vares, D. , Buckner, C. , Lafrenie, R. and Persinger, M. (2014) Magnetic Field Configurations Corresponding to Electric Field Patterns That Evoke Long-Term Potentiation Shift Power Spectra of Light Emissions from Microtubules from Non-Neural Cells. Open Journal of Biophysics, 4, 112-118. doi: 10.4236/ojbiphy.2014.44013.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Malenka, R.C. and Bear, M.F. (2004) LTP and LTD: An Embarrassment of Riches. Neuron, 44, 5-21.
[2] Moser, M.-B., Tommald, M. and Andersen, P. (1994) An Increase of Dendritic Spine Density on Hippocampal CA1 Pyramidal Cells Following Spatial Learning In Adult Rats Suggests The Formation of New Synapses. Proceedings for the National Academy of Sciences, U.S.A., 91, 12673-12675.
[3] Whitlock, J.R., Heynen, A.J., Shuler, M.G. and Bear, M.F. (2006) Learning Induces Long-Term Potentiation in the Hippocampus. Science, 313, 1093-1097.
[4] Persinger, M.A. (2010) 10-20 Joules as a Neuromolecular Quantum in Medicinal Chemistry: An Alterative Approach to the Myriad of Molecular Pathways. Current Medicinal Chemistry, 17, 3094-3098.
[5] Rose, G.M., Diamond, D.M., Pang, K. and Dunwiddie, T.V. (1988) Primed Burst Potentiation: Lasting Synaptic Plasticity Invoked by Physiologically Patterned Stimulation. In: Hass, H. and Buzaski, G., Eds., Synaptic Plasticity in the Hippocampus, Springer-Verlag, Berlin, 96-98.
[6] Mach, Q.-H. and Persinger, M.A. (2009) Behavioral Changes with Brief Exposures to Weak Magnetic Fields Patterned to Simulate Long-Term Potentation. Brain Research, 1261, 45-53.
[7] Hameroff, S. and Penrose, S. (2014) Consciousness in the Universe: A Review of the “Orch OR” Theory. Physics of Life Reviews, 11, 39-78.
[8] Dotta, B.T., Buckner, C.A., Cameron, D., Lafrenie, R.F. and Persinger, M.A. (2011) Biophoton Emission from Cell Cultures: Biochemical Evidence for the Plasma Cell Membrane as the Primary Source. General Physiology and Biophysics, 30, 301-309.
[9] Dotta, B.T., Lafrenie, R.M., Karbowski, L.M. and Persinger, M.A. (2014) Photon Emission from Melanoma Cells during Brief Stimulation by Patterned Magnetic Fields: Is the Source Coupled to Rotational Diffusion within the Membrane? General Physiology and Biophysics, 33, 63-73.
[10] Dotta, B.T. and Persinger, M.A. (2012) “Doubling” of Local Photon Emissions When Two Simultaneous, Spatially Separated, Chemiluminescent Reactions Share the Same Magnetic Field Configurations. Journal of Biophysical Chemistry, 3, 72-80.
[11] Konig, H.L., Krueger, A.P., Lang, S. and Sonning, W. (1981) Biological Effects of Environmental Electromagnetism, Springer-Verlag, New York.
[12] McKay, B.E., Persinger, M.A. and Koren, S.A. (2000) Exposure to a Theta-Burst Magnetic Field Impairs Memory Acquisition and Consolidation for Contextual but Not Discrete Conditioned Fear in Rats. Neuroscience Letters, 292, 99-102.
[13] Cifra, M., Fields, J.Z. and Farhadi, A. (2011) Electromagnetic Cellular Interactions. Progress in Biophysics and Molecular Biology, 105, 223-246.
[14] Isojima, Y., Isoshima, T., Nagai, K., Kikuchi, K. and Nakagawa, H. (1995) Ultraweak Biochemiluminescence Detected from Rat Hippocampal Slices. NeuroReport, 6, 658-660.
[15] Alonso, A. and Klink, R. (1993) Differential Electroresponsiveness of Stellate and Pyramidal-Like Cells of Medial Entorhinal Cortex Layer II. Journal of Neurophysiology, 70, 128-143.

Copyright © 2023 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.