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Pulmonary Complications as a Cause of Death after Renal Transplantation

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DOI: 10.4236/ojim.2014.42007    2,442 Downloads   3,280 Views   Citations

ABSTRACT

Objectives: To analyse the risk factors for death as a result of pulmonary complications in kidney transplant patients. Material and Methods: 267 patients after renal transplantation were prospectively studied. The kidney recipients were followed for the development of pulmonary complications and their outcome for a period of 7 years. Different noninvasive and invasive diagnostic tests were used in cases suspected for lung disease. Results: Risk factors for death as a result of pulmonary complications are development of lung diseases in the first six months after operation (P < 0.05), and immunosuppressive regimens that include mycophenolate mofetil (HR: 3.216; 95% CI: 1.067 - 5.577; P = 0.011). The factors associated with lower rate of fatal outcome are positive serology test for Cytomegalovirus of the recipient before transplantation (P = 0.034) and use of azathioprine (HR: 0.720; 95% CI: 0.526 - 0.986; P = 0.04). Conclusions: The risk factors may be used to identify patients at increased risk for death due to the pulmonary complications. Strictly monitoring of higher-risk patients can reduce the morbidity and mortality after renal transplantation.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Pencheva, V. , Petrova, D. , Genov, D. and Georgiev, O. (2014) Pulmonary Complications as a Cause of Death after Renal Transplantation. Open Journal of Internal Medicine, 4, 41-46. doi: 10.4236/ojim.2014.42007.

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