Investigate Evaluation of Oxidative Stress and Lipid Profile in STZ-Induced Rats Treated with Antioxidant Vitamin

Abdella Emam Abdella Baragob, Waleed Hassan AlMalki, Hassan Elsiddig Hassan Farag Alla, Asim Ibrahim, Salwa Khojali Muhammed, Samia Abdella

Department of Pharmaceuticalchemistry, Faculty of Pharmacy, Umm Al Qura University, Makkah, Saudi Arabia.
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Umm Al Qura University, Makkah, Saudi Arabia.
Department of Public Health, Health Sciences College at Al-lieth, Umm Al Qura University, Makkah, Saudi Arabia; Department of Histopathology and Cytology, College of Medical La-boratory Science, Sudan University of Science and Technology, Khartoum, Sudan.
Veterinary Research Institute, Department of Biochemistry, Khartoum, Sudan.
Veterinary Research Institute, Department of Pharmacology, Khartoum, Sudan.

DOI: 10.4236/pp.2014.53034                

Abstract

The objective of this study was designed to investigate, evaluate the effect of vitamin E on streptozotocin (STZ)-induced diabetic rats by showing significant changes in blood glucose, water, food intake, lipid profile, serum urea and ceratinine level, and antioxidant enzyme parameters activity. Streptozotocin (STZ)-induced toxicity was studied in male Waster rats; each divided into four groups: G1, GII, GIII, and GIV. Control rats GI, rats treated with vitamin E (GII), STZ-induced diabetic rats (GIII), and STZ-induced diabetic rats treated with vitamin E (G1V). Moreover, vitamin E reduced (p < 0.05) blood glucose and urea, thus, our study improved the lipid profile (reduced the serum levels of amount of total cholesterol, LDL, VLDL, cholesterol and triacyglycerols, and increased HDL cholesterol) and increased total amount protein in STZ-induced diabetic rats (GIV). Vitamin prevented modification in the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSX-Px) and in the concentration of the lipid hydroperoxide. Finally the study suggested that vitamin E improved hyperglycaemia and dyslipidaemia while inhibiting the progression of oxidative stress in STZ-induced diabetic rats.

Keywords

Investigate; Lipid; Profile; STZ; Oxidative Stress; Vitamin E

Conflicts of Interest

The authors declare no conflicts of interest.

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