Overview on the Fungal Metabolites Involved in Mycopathy (Review Paper)

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DOI: 10.4236/ojmm.2014.41006    5,594 Downloads   8,882 Views   Citations

ABSTRACT

This review presents several types of metabolites produced by the most common fungal pathogens and their roles in fungal pathogenesis. Toxic metabolites from toxigenic fungi include compounds such as aflatoxins, trichothecenes, ochratoxins, fumonisins, zearalenone and ergot alkaloids, which display hepatotoxicity, nephrotoxicity, neurotoxicity and genotoxicity. The ability of fungi to produce and elaborate hydrolytic enzymes is associated with virulence of several pathogenic fungi. The biogenesis of siderophores is investigated as it is a mechanism of iron acquisition. In particular, these metabolites act as iron chelators and storage compounds to support pathogenic fungi to survive in mammalian hosts whose iron homeostasis is strictly regulated and prevent the formation of free radicals which are formed by free iron. Melanins clearly promote infectivity in a number of species of fungal pathogens. They interfere with oxidative metabolism of phagocytosis making the fungus relatively resistant to phagocyte attack. Several metabolies such as pullulan, mannitol, β-(1,3)-glucan, hem-binding proteins, estrogen-binding proteins, farnesol, agglutinin-like sequence proteins, glucuronoxylomannan and others also have advantages in fungal pathogenicity. The identification of fungal metabolites involved in pathogenesis, and recognition of mechanisms of pathogenesis may lead to development of new efficient anti-fungal therapies.

Cite this paper

Al-Fakih, A. (2014) Overview on the Fungal Metabolites Involved in Mycopathy. Open Journal of Medical Microbiology, 4, 38-63. doi: 10.4236/ojmm.2014.41006.

Conflicts of Interest

The authors declare no conflicts of interest.

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(2002) 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" 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