Active substance applicator to remove the disturbances in the fluid flow


The paper presents the construction of an automatic applicator of active substance that removes causes of the disturbances in the fluid flow in a system that is under the control. In a particular case, it can be applied to the removal of disturbances in the blood flow in vessels caused by a thrombus formation (e.g. post-operative or due to dialysis treatment). The presented applicator automatically releases the active substance into the system while detecting in real time the abnormal fluid flow. It allows mixing the active substance (e.g. anticoagulant drug) with the controlled medium outside the substance container (e.g. serum) while offering the possibility of the repeated usage.

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Grzegorczyn, J. , Trompeta, J. , Wróbel, A. and Kubica, K. (2014) Active substance applicator to remove the disturbances in the fluid flow. Journal of Biomedical Science and Engineering, 7, 115-118. doi: 10.4236/jbise.2014.73016.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Fox, C.S. and Coady, S. (2007) Increasing cardiovascular disease burden due to diabetes mellitus: The Framingham heart study. Circulation, 115, 1544-1550.
[2] Ku, D. (1997) Blood flow in arteries. Annual Review of Fluid Mechanics, 29, 399-434.
[3] Rancic, Z., Pfammatter, T., et al. (2009) Floating aortic arch thrombus involving the supraaortic trunks: Successful treatment with supra-aortic debranching and antegrade endograft implantation. Journal of Vascular Surgery, 50, 1177-1180.
[4] Bagot, C. and Arya, R. (2008) Virchow and his triad: A question of attribution. British Journal of Haematology, 143, 180-190.
[5] Pizzo, S.V., Schwartz, M.L., Hill, R.L. and McKee, P.A. (1972) Mechanism of ancrod anticoagulation. A direct proteolytic effect on fibrin. Journal of Clinical Investment, 51, 2841-2850.
[6] Castroa, H.C., Zingali, R.B., Albuquerquec, M.G., Pujol-Luza, M. and Rodriguesd, C.R. (2004) Snake venom thrombin-like enzymes: From reptilase to now. Cellular and Molecular Life Sciences, 61, 843-856.
[8] Chlupác, J., Filová, E. and Bacáková, L. (2009) Blood vessel replacement: 50 years of development and tissue engineering paradigms in vascular surgery. Physiological Research, 58, 119-139.

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