An Innovative Concept Gel to Prevent Skin Aging


The study aimed to evaluate the instrumental and clinical properties of an innovative gel formulation for anti-aging treatment. This was an open, non-controlled study, where the eligible subjects, divided into three subgroups according to age, had to perform a single dose application of the gel on the face for a short-term evaluation and a 4-week repeated use, twice a day, for a long-term evaluation. Instrumental and clinical evaluations had to be performed mono-laterally at the level of the face (right or left side according to a predisposed randomization list) in basal conditions (T0), 20 minutes after the first dose application (T20min) and after 2 and 4 weeks of treatment (T2wks - T4wks). Thirty-three subjects completed the study showing, after only 20 minutes from the 1st product application, a clinically important and statistically significant improvement of crow’s feet, skin dullness clinical score and cutaneous microrelief clinical score (p < 0.05), after 2 weeks of treatment an improvement of skin tonicity (p < 0.05) and after 4 weeks of treatment having a significant decrease of nasolabial folds clinical score (p < 0.05). The study showed the great efficacy of an innovative anti-aging gel in reducing the skin roughness and skin dryness, improving the skin firmness and, in general, providing a global skin rejuvenation.

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A. Sparavigna, B. Tenconi, I. Deponti, F. Scarci, M. Caserini and F. Mailland, "An Innovative Concept Gel to Prevent Skin Aging," Journal of Cosmetics, Dermatological Sciences and Applications, Vol. 3 No. 4, 2013, pp. 271-280. doi: 10.4236/jcdsa.2013.34041.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] I. Ghersetich, M. Troiano, V. De Giorgi and T. Lotti, “Receptors in Skin Ageing and Anti-Aging Agents,” Dermatologic Clinics, Vol. 25, No. 4, 2007, pp. 655-662.
[2] G. J. Fisher, J. Varani and J. J. Voorhees, “Looking older: Fibroblast Collapse and Therapeutic Implications,” JAMA Dermatology, Vol. 144, No. 5, 2008, pp. 666-672. archderm.144.5.666
[3] M. Wlaschek, et al., “Solar UV Irradiation and Dermal Photoaging,” Journal of Photochemistry and Photobiology B: Biology, Vol. 63, No. 1-3, 2001, pp. 41-51. (01)00201-9
[4] W. Ma, et al., “Chronological Ageing and Photoageing of the Fibroblasts and the Dermal Connective Tissue,” Clinical and Experimental Dermatology, Vol. 26, No. 7, 2001, pp. 592-599.
[5] G. J. Fisher, “The Pathophysiology of Photoaging of the Skin,” Cutis, Vol. 75, No. 2S, 2005, pp. 5-9.
[6] L. D. Muiznieks, A. S. Weiss and F. W. Keeley, “Structural Disorder and Dynamics of ELastin,” Biochemistry and Cell Biology, Vol. 88, No. 2, 2010, pp. 239-250.
[7] F. W. Danby, “Nutrition and Aging Skin: Sugar and Glycation,” Clinics in Dermatology, Vol. 4, No. 28, 2010, pp. 409-411.
[8] M. F. Demierre, et al., “Public Knowledge, Awareness, and Perceptions of the Association between Skin Aging and Smoking,” Journal of the American Academy of Dermatology, Vol. 41, No. 1, 1999, pp. 27-30.
[9] E. Makrantonaki, et al., “Skin and Brain Age Together: The Role of Hormones in the Ageing Process,” Experimental Gerontology, Vol. 45, No. 10, 2010, pp. 801-813. 2010.08.005
[10] J. K. Rivers, “The Role of Cosmeceuticals in Antiaging Therapy,” Skin Therapy Letters, Vol. 13, No. 8, 2008, pp. 5-9.
[11] US Food Drug Administration, “Alpha Hydroxy Acids in Cosmetics,” US Food Drug Administration, Silver Spring, 2013. Ingredients/ucm107940.htm
[12] A. Sparavigna, M. Setaro and A. Di Pietro, “Healthy Skin 2005: Results of Italian Study on Healthy Population with Particular Regard to the Ageing Phenomenon,” Journal of Plastic Dermatology, Vol. 2, 2006, pp. 23-29.
[13] T. Pavicic, et al., “Efficacy of Cream-Based Novel Formulations of Hyaluronic Acid of Different Molecular Weights in Anti-Wrinkle Treatment,” Journal of Drugs in Dermatology, Vol. 10, No. 9, 2011, pp. 990-1000.
[14] N. Philips, et al., “Direct Inhibition of Elastase and Matrixmetalloproteinases and Stimulation of Biosynthesis of Fibrillar Collagens, Elastin, and Fibrillins by Xanthohumol,” Journal of Cosmetic Science, Vol. 61, No. 2, 2010, 2006, pp. 125-132.
[15] E. Bocchietto, “Polichem Internal Data,” 2013. Unpublished.

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